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Figure 4 | Molecular Autism

Figure 4

From: N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism

Figure 4

NSF knockdown results in decreased uptake function of SERT in HEK293-hSERT cells. Fluorescent substrate uptake activity was significantly decreased in HEK293-hSERT cells transfected with siRNAs targeting specific NSF sequences, siRNA-1 () and siRNA-2 (▲), compared with negative control () (control vs siRNA-1 P < 0.01, and control vs siRNA-2 P < 0.001, one-way repeated measures ANOVA with Tukey’s post hoc test). Nonspecific uptake was determined in the presence of 10 μM fluoxetine (■). Data are expressed as a percentage of the control level. Each point corresponds to the mean ± standard deviation, n = 8. siRNA, small interfering RNA.

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