Working model integrating our experimental results. Dlgap2−/−mice have shorter and thinner PSDs, fewer receptors allocating on the scaffolds, reduced presynaptic release probability and decreased spine density in the OFC. Due to the obvious disruptions in the OFC, Dlgap2−/−mice display exacerbated aggressive behaviors. AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; OFC, orbitofrontal cortex. NMDA, N-Methyl-D-aspartic acid.