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Figure 6 | Molecular Autism

Figure 6

From: Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits

Figure 6

Deficits of synaptic transmission in orbitofrontal cortex of Dlgap2−/−mice. (A) Example traces of mEPSCs from Dlgap2+/+ (WT) and Dlgap2−/− (KO) mice. (B) Decreased amplitude of mEPSCs in the OFC of Dlgap2−/−mice. n = 30 to 35 neurons from five Dlgap2+/+ (WT) and five Dlgap2−/− (KO) mice. Data are presented as a cumulative frequency curve of mEPSCs and bar graph. (C) Representative traces of the paired-pulse ratio from Dlgap2+/+ (WT) and Dlgap2−/− (KO) mice. The first pulse is indicated by ‘1’. A paired-pulse at 25 ms interval is indicated by ‘2’, a paired-pulse at 50 ms interval by ‘3’ and a paired-pulse at 100 ms interval by ‘4’. (D) Paired-pulse ratio, which was enhanced for Dlgap2−/− (KO) mice. n = 7 to 11 neurons per inter-stimulus interval from four Dlgap2+/+ (WT) and three Dlgap2−/− (KO) mice. *P < 0.05 and ***P < 0.001 from two-tailed t-test for (B) and two-way ANOVA for (D). KO, knockout; WT, wild type.

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