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Figure 4 | Molecular Autism

Figure 4

From: Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits

Figure 4

Downregulation of synaptic scaffold proteins and receptors in the cortex of Dlgap2−/−mice. (A) Quantities of synaptic receptor proteins NR1 and GluR1 were decreased in cortical synaptosomal fractions from Dlgap2−/−mice. (B) Quantities of synaptic scaffold proteins Homer-1b/c and αCaMKII were reduced in cortical synaptosomal fractions from Dlgap2−/−mice. Data are presented as mean ± standard error of the mean. n =6 for each genotype. *P < 0.05 and ***P < 0.001 from a two-tailed t-test. KO, knockout; WT, wild type.

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