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Figure 3 | Molecular Autism

Figure 3

From: Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice

Figure 3

Alternative splicing of Shank3 in different brain regions and across development. (A) Splicing of Shank3 coding exons in different brain regions. (B) Quantification for splicing of E10–12S III to IV in (A). The values of the spliced bands were normalized to E10–12S I without splicing. (C) Quantification for splicing of exon 18 in (A) . Values were shown as the ratio of exon18 (-) to exon18 (+). (D) Splicing of Shank3 coding exons during brain development. (E) Quantification for splicing of E10–12S III in (D), values of the spliced products were normalized to that of E10–12S I without splicing. (F) Quantification for splicing of exon 18 of Shank3e in (D) . All data are shown as mean ± SEM. The abbreviations for different brain regions and ages are the same as in Figure 2.

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Molecular Autism

ISSN: 2040-2392