Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum

Table 1 Clinical characteristics and RNA quality of autistic and control brain samples

Sample#	UMB #	Diagnosis	Brain area	Age (yr)	Cause of death	PMI (h)	RNA quality
Sample#	UMB #	Diagnosis	Brain area	Age (yr)	Cause of death	PMI (h)	A260/280	A260/230	RIN
1	5308*	Autism	PFC	4.5	Skull fracture	21	2.051	2.266	4.9
2	1349	Autism	PFC	5.6	Drowning	39	2.044	2.232	4.3
3	5144	Autism	PFC	7.2	Rhabdomyosarcoma	3	2.058	2.271	5.4
4	5302*	Autism	PFC	16.3	DKA	20	2.031	2.238	4
5	4999*	Autism	PFC	20.8	Cardiac arrhythmia	14	2.039	2.232	6
6	4670*	Control	PFC	4.6	Commotio Cordis	17	2.048	2.276	5.2
7	1185	Control	PFC	4.7	Drowning	17	2.026	2.243	4.7
8	4898	Control	PFC	7.7	Drowning	12	2.056	2.183	5.9
9	4848*	Control	PFC	16.7	Drowning	15	2.044	2.185	6.7
10	4727*	Control	PFC	20.5	Multiple injuries (MVA)	5	2.066	2.209	6.5
11	5308*	Autism	Cere	4.5	Skull fracture	21	2.087	1.781	7.3
12	4899	Autism	Cere	14.3	Drowning	9	2.077	2.314	9.3
13	5302*	Autism	Cere	16.3	DKA	20	2.083	1.646	2.2
14	4999*	Autism	Cere	20.8	Cardiac arrhythmia	14	2.081	2.114	9.2
15	4670*	Control	Cere	4.6	Commotio Cordis	17	2.088	2.161	6.1
16	4722	Control	Cere	14.5	Multiple injuries (ATV)	16	2.073	2.828	6.5
17	4848*	Control	Cere	16.7	Drowning	15	2.087	2.327	6.8
18	4727*	Control	Cere	20.5	Multiple Injuries (MVA)	5	2.067	2.307	7.2

PFC: Prefrontal cortex; Cere: Cerebellum; UMB: University of Maryland Brain Bank sample number; PMI: Post-mortem interval; DKA: Diabetic ketoacidosis; ATV: All-terrain vehicle; MVA: Motor vehicle accident; RIN: RNA integrity number. *Indicates both prefrontal cortex and cerebellum samples were assessed from the same donor brain.

ISSN: 2040-2392