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Table 2 Top-ranked biological functions enriched in probes differentially expressed (P < 0.01) from IPA

From: Transcriptomic changes in the frontal cortex associated with paternal age

Biological function

P value

Maturation of dendritic cells

8.99 × 10-5

Influx of phagocytes

1.69 × 10-4

Binding of interferon-stimulated response element

6.43 × 10-4

Damage of oligodendrocytes

7.00 × 10-4

Lack of mesenteric lymph node

7.00 × 10-4

Lack of peripheral lymph node

7.00 × 10-4

Stimulation of hyaluronic acid

7.00 × 10-4

Morphology of tooth

7.56 × 10-4

Activation of myeloid cells

7.78 × 10-4

Clustering of lymph node cells

1.16 × 10-3

Osteoclastogenesis of bone cell lines

1.16 × 10-3

Transmigration of Th1 cells

1.16 × 10-3

Influx of neutrophils

1.21 × 10-3

Proliferation of dendritic cells

1.27 × 10-3

Destruction of joint

1.47 × 10-3

Arrest in cell cycle progression of endothelial cells

1.73 × 10-3

Lack of cervical lymph node

1.73 × 10-3

Organogenesis of lymphoid organ

1.73 × 10-3

Response of carcinoma cell lines

1.73 × 10-3

Extravasation of myeloid cells

1.92 × 10-3

Morphogenesis of neurites

1.97 × 10-3

Induction of neuroglia

2.40 × 10-3

Quantity of IL-5 In blood

2.40 × 10-3

Quantity of multinucleated cells

2.40 × 10-3

Response of lung cancer cell lines

2.40 × 10-3

Activation of monocytes

2.45 × 10-3

Acne

2.48 × 10-3

Formation of osteoclasts

2.60 × 10-3

Mobilization of blood cells

2.63 × 10-3

Activation of phagocytes

2.69 × 10-3

Binding of lymphoma cell lines

2.76 × 10-3

Cell viability of blood cells

2.82 × 10-3

Quantity of tooth

3.17 × 10-3

Activation of macrophages

3.23 × 10-3

Proliferation of B lymphocytes

3.35 × 10-3

Response of connective tissue cells

3.42 × 10-3

Cell movement of dendritic cells

3.88 × 10-3