Figure 3From: DAWN: a framework to identify autism genes and subnetworks using gene expression and geneticsAnalysis of MIPS validation experiment. (A) First 44 genes with prior de novo mutations were sequenced for 2,448 additional trios. These genes were cross-classified by whether or not they had a prior dnLoF mutation, and whether or not they were on the DAWN rASD list (yes: red, no: blue). For each category, the percentage of genes that had a dnLoF mutation in the new trios is depicted.(B) For a given gene, the probability of observing a dnLoF mutation in 2,500 probands varies. This probability is compared for four types of genes: a randomly chosen gene and three classifications of the genes from the MIPS experiment including: (i) all 44 genes, (ii) those 16 genes with a prior dnLoF mutation and (iii) those 10 genes on the rASD list. dnLoF, de novo loss of function; rASD, risk autism spectrum disorder.Back to article page