Network of risk ASD (rASD) genes. These genes met the false discovery rate threshold of.05. The intensity of the red reflects the magnitude of the netscore based on TADA statistics from neighboring genes. Large nodes depict genes that have at least one dnLoF mutation. CUL3, DYRK1A, GRIN2B, POGZ, SCN2A and TBR1 are genes with multiple dnLoF mutations. Edges connect genes with absolute correlation of.7 or greater based on periods 3–5 or 4–6. dnLoF, de novo loss of function; rASD, risk autism spectrum disorder; TADA, transmission and de novo association.