The DAWN algorithm. (A) Each node in the network represents a gene and each edge represents pairs of genes with strong co-expression (absolute correlation r>0.7). (B) Orange nodes indicate genes with strong genetic scores from the TADA test. (C) Hot spots (i.e., clusters of strong scores) are classified as nASD genes in the screening stage of the algorithm; cool spots (i.e. strong scores in isolation) are not.(D) In the final cleaning step, the nASD list is further refined to reveal the rASD gene list. This step uses the TADA scores and features of the network to compute the false discovery rate of each gene. FDR, false discovery rate; nASD, network autism spectrum disorder; rASD, risk autism spectrum disorder; TADA, transmission and de novo association.