Figure 2

Gene expression in 40,XY and 39,X^Y*O adult brain regions. Of six candidate genes confirmed as being differentially expressed by microarray and known to be expressed in the hippocampus, two were significantly downregulated in this brain region in 39,X^Y*O mice (Erdr1 and C1qc); a third gene, Dhcr7, implicated in serotonergic neurodevelopmental phenotypes, was also downregulated in mutant mice (A). Erdr1 and C1qc were also significantly downregulated in the 39,X^Y*O striatum (B).*P < 0.05, **P < 0.01, ***P < 0.001.