Table 1 Summary of the findings in previous studies that investigated the effect of oxytocin in ASD
Study | Oxytocin application | Major findings |
|---|---|---|
Hollandar et al. (2003) [21] | Intravanous | Reduced repetitive behaviors |
Hollandar et al. (2007) [25] | Intravanous | Improved affective speech comprehension |
Guastella et al. (2010) [23] | Intranasal (single dose) | Improved performance in Reading-the-Mind-in-the-Eyes Test |
Andari et al. (2010) [22] | Intranasal (single dose) | Improved social behaviors, subjective feeling of trust, gazing behaviors at the eye region |
Anagnostou et al. (2012) [24] | Intranasal (6Â weeks) | No change in Diagnostic Analysis of Nonverbal Accuracy & Repetitive Behavior Scale Revised; improved performance in Reading-the-Mind-in-the-Eyes Test and quality of life |
Domes et al. (2013) [26] | Intranasal (single dose) | Increased brain activity patterns in the right amygdala during face processing |