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Table 2 Enriched pathways in blood and brain of Tsc2+/− mice

From: Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis

KEGG categories

Name

SIZE

NES

NOM p-val

FDR q-val

Brain

     

Immune system

HSA04060 Cytokine-cytokine receptor interaction

212

2.37

< 0.0005

< 0.0005

 

HSA04640 Hematopoietic cell lineage

66

1.75

< 0.0005

0.0389

Signaling pathways

HSA04010 MAPK signaling pathway

241

−1.92

< 0.0005

0.0431

 

HSA01430 Cell communication

118

2.15

< 0.0005

0.0007

Translation

HSA03010 Ribosome

66

3.21

< 0.0005

< 0.0005

Metabolism

HSA00563 Glycosylphosphatidylinositol anchor biosynthesis

21

−1.85

0.0017

0.0444

 

HSA00190 Oxidative phosphorylation

110

2.75

< 0.0005

< 0.0005

 

HSA00980 Metabolism of xenobiotics by cytochrome P450

35

1.77

< 0.0005

0.0379

Blood

     

Nervous system

HSA05010 Alzheimer’s disease

26

1.92

< 0.0005

0.0034

Immune system

HSA04620 Toll-like receptor signaling pathway

94

2.00

< 0.0005

0.0016

 

HSA04662 B cell receptor signaling pathway

60

1.85

< 0.0005

0.0072

Cell growth and death

HSA04110 Cell cycle

107

−2.31

< 0.0005

0.0005

 

HSA04210 Apoptosis

73

1.78

0.0006

0.0181

Translation

HSA03010 Ribosome

66

1.68

0.0026

0.0468

Metabolism

HSA01032 Glycan structures degradation

29

2.16

< 0.0005

0.0000

 

HSA00530 Aminosugars metabolism

29

1.95

0.0007

0.0035

 

HSA00531 Glycosaminoglycan degradation

17

1.92

< 0.0005

0.0043

 

HSA00511 Other glycan degradation

15

1.88

0.0007

0.0047

 

HSA00600 Sphingolipid metabolism

31

1.69

0.0064

0.0473