Skip to main content

Table 2 Enriched pathways in blood and brain of Tsc2+/− mice

From: Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis

KEGG categories Name SIZE NES NOM p-val FDR q-val
Brain      
Immune system HSA04060 Cytokine-cytokine receptor interaction 212 2.37 < 0.0005 < 0.0005
  HSA04640 Hematopoietic cell lineage 66 1.75 < 0.0005 0.0389
Signaling pathways HSA04010 MAPK signaling pathway 241 −1.92 < 0.0005 0.0431
  HSA01430 Cell communication 118 2.15 < 0.0005 0.0007
Translation HSA03010 Ribosome 66 3.21 < 0.0005 < 0.0005
Metabolism HSA00563 Glycosylphosphatidylinositol anchor biosynthesis 21 −1.85 0.0017 0.0444
  HSA00190 Oxidative phosphorylation 110 2.75 < 0.0005 < 0.0005
  HSA00980 Metabolism of xenobiotics by cytochrome P450 35 1.77 < 0.0005 0.0379
Blood      
Nervous system HSA05010 Alzheimer’s disease 26 1.92 < 0.0005 0.0034
Immune system HSA04620 Toll-like receptor signaling pathway 94 2.00 < 0.0005 0.0016
  HSA04662 B cell receptor signaling pathway 60 1.85 < 0.0005 0.0072
Cell growth and death HSA04110 Cell cycle 107 −2.31 < 0.0005 0.0005
  HSA04210 Apoptosis 73 1.78 0.0006 0.0181
Translation HSA03010 Ribosome 66 1.68 0.0026 0.0468
Metabolism HSA01032 Glycan structures degradation 29 2.16 < 0.0005 0.0000
  HSA00530 Aminosugars metabolism 29 1.95 0.0007 0.0035
  HSA00531 Glycosaminoglycan degradation 17 1.92 < 0.0005 0.0043
  HSA00511 Other glycan degradation 15 1.88 0.0007 0.0047
  HSA00600 Sphingolipid metabolism 31 1.69 0.0064 0.0473