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Table 1 Enriched pathways in blood and brain of Fmr1 knockout mice

From: Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis

KEGG categories Name SIZE NES NOM p-val FDR q-val
Brain      
Nervous system HSA04080 Neuroactive ligand receptor interaction 223 2.34 < 0.0005 0.0000
  HSA04720 Long-term potentiation 62 −2.15 < 0.0005 0.0023
  HSA04540 Gap junction 77 −1.75 < 0.0005 0.0429
  HSA04360 Axon guidance 125 −1.81 < 0.0005 0.0480
Immune system HSA04060 Cytokine-cytokine receptor interaction 212 2.72 < 0.0005 < 0.0005
  HSA04610 Complement and coagulation cascades 47 2.32 < 0.0005 < 0.0005
  HSA04650 Natural killer cell mediated cytotoxicity 95 1.70 0.0015 0.0379
  HSA04612 Antigen processing and representation 42 1.67 0.0049 0.0397
  HSA04640 Hematopoietic cell lineage 66 2.09 < 0.0005 0.0004
Signaling pathways HSA01430 Cell communication 118 2.14 < 0.0005 0.0004
  HSA04630 Jak-STAT signaling pathway 137 2.07 < 0.0005 0.0005
  HSA04070 Phosphatidylinositol signaling system 65 1.77 0.0029 0.0420
  HSA04910 Insulin signaling pathway 126 1.80 < 0.0005 0.0455
Metabolism HSA00150 Androgen and estrogen metabolism 33 1.84 0.0043 0.0118
  HSA00590 Arachidonic acid metabolism 39 1.81 0.0017 0.0147
  HSA00361 γ-hexachlorocyclohexane degradation 17 1.69 0.0118 0.0370
  HSA00020 Citrate cycle 25 1.93 0.0023 0.0375
  HSA00592 α-linolenic acid metabolism 15 1.70 0.0127 0.0392
  HSA00251 Glutamate metabolism 30 1.87 0.0038 0.0430
Folding, sorting, and degradation HSA04120 Ubiquitin mediated proteolysis 36 1.78 0.0039 0.0453
  HSA04130 Snare interactions in vesicular transport 29 1.84 < 0.0005 0.0450
Blood      
Signaling pathways HSA04070 Phosphatidylinositol signaling system 65 1.78 < 0.0005 0.0500