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Table 1 Enriched pathways in blood and brain of Fmr1 knockout mice

From: Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis

KEGG categories

Name

SIZE

NES

NOM p-val

FDR q-val

Brain

     

Nervous system

HSA04080 Neuroactive ligand receptor interaction

223

2.34

< 0.0005

0.0000

 

HSA04720 Long-term potentiation

62

−2.15

< 0.0005

0.0023

 

HSA04540 Gap junction

77

−1.75

< 0.0005

0.0429

 

HSA04360 Axon guidance

125

−1.81

< 0.0005

0.0480

Immune system

HSA04060 Cytokine-cytokine receptor interaction

212

2.72

< 0.0005

< 0.0005

 

HSA04610 Complement and coagulation cascades

47

2.32

< 0.0005

< 0.0005

 

HSA04650 Natural killer cell mediated cytotoxicity

95

1.70

0.0015

0.0379

 

HSA04612 Antigen processing and representation

42

1.67

0.0049

0.0397

 

HSA04640 Hematopoietic cell lineage

66

2.09

< 0.0005

0.0004

Signaling pathways

HSA01430 Cell communication

118

2.14

< 0.0005

0.0004

 

HSA04630 Jak-STAT signaling pathway

137

2.07

< 0.0005

0.0005

 

HSA04070 Phosphatidylinositol signaling system

65

1.77

0.0029

0.0420

 

HSA04910 Insulin signaling pathway

126

1.80

< 0.0005

0.0455

Metabolism

HSA00150 Androgen and estrogen metabolism

33

1.84

0.0043

0.0118

 

HSA00590 Arachidonic acid metabolism

39

1.81

0.0017

0.0147

 

HSA00361 γ-hexachlorocyclohexane degradation

17

1.69

0.0118

0.0370

 

HSA00020 Citrate cycle

25

1.93

0.0023

0.0375

 

HSA00592 α-linolenic acid metabolism

15

1.70

0.0127

0.0392

 

HSA00251 Glutamate metabolism

30

1.87

0.0038

0.0430

Folding, sorting, and degradation

HSA04120 Ubiquitin mediated proteolysis

36

1.78

0.0039

0.0453

 

HSA04130 Snare interactions in vesicular transport

29

1.84

< 0.0005

0.0450

Blood

     

Signaling pathways

HSA04070 Phosphatidylinositol signaling system

65

1.78

< 0.0005

0.0500