Figure 4

Linkage in regions of interest from previous studies: combined sample. Logarithm of odds (LOD) scores from non-parametric, multipoint linkage analysis for autism spectrum disorder affection status in the combined sample (Merlin) are plotted for chromosomes with suggestive linkage peaks (LOD ≥2.2) from previous studies. Colored bars and black marks indicate the spans and peaks of linkage regions of interest, respectively; text indicates the linkage region source (L, Liu et al., 2001 [26]; Y, Yonan et al., 2003 [34]; St, Stone et al., 2004 [28]; C, Cantor et al., 2005 [25]; M, McCauley et al., 2005 [27]; Sz, Szatmari et al., 2007 [32]; W, Weiss et al., 2009 [33]; green and ALL, all multiplex families; blue and MO, male-only families; red and FC, female-containing families). Dashed lines mark LOD thresholds of 2.2 for suggestive and 3.6 for significant linkage.