Behavioral signatures related to genetic disorders in autism

Table 1 Characteristics of the total genetic disorder sample

Genetic disorder	N			Age (months)	ASD		ADI-R scores per domain and total scores				IQ
Genetic disorder	Total	Female	Male	Age (months)	Yes	No	I	II	III	Total	IQ
22q11DS	90	42	48	162.5 ± 33.6	40	50	9.8 ± 6.4	7.7 ± 4.8	2.5 ± 2.2	20.0 ± 12.0	67.0 ± 14.1
Down’s	21	16	5	169.1 ± 32.6	6	15	7.2 ± 4.4	6.8 ± 3.8	3.2 ± 2.0	17.2 ± 8.6	49.5 ± 11.9
PWS	88	48	40	191.9 ± 141.0	20	68	7.9 ± 5.1	5.7 ± 4.5	2.8 ± 2.0	16.3 ± 10.1	70.9 ± 16.3
SMC15	22	8	14	161.4 ± 103.6	19	3	15.6 ± 6.0	13.6 ± 5.5	6.5 ± 2.4	35.7 ± 12.2	51.0 ± 19.0
TSC	50	31	19	126.2 ± 74.0	22	28	12.0 ± 9.0	9.6 ± 6.8	3.7 ± 3.3	25.2 ± 17.9	69.3 ± 27.4
XXY	51	0	51	145.4 ± 41.4	16	35	8.5 ± 6.0	8.8 ± 5.4	2.3 ± 2.1	19.6 ± 12.0	80.4 ± 13.9
Total	322	145	177		123	199
Average				162.7 ± 89.8			9.6 ± 6.7	8.0 ± 5.6	3.1 ± 2.5	20.6 ± 13.4	68.6 ± 19.2

Data provided are mean values and, if applicable, standard error of the means. ADI-R domains: I, qualitative abnormalities in reciprocal social interaction; II, qualitative abnormalities in communication; and III, restricted, repetitive and stereotyped patterns of behavior. 22q11DS, 22q11.2 deletion syndrome; ADI-R, Autism Diagnostic Interview-Revised; ASD, autism spectrum disorder; Down’s, Down’s syndrome; PWS, Prader-Willi syndrome; SMC15, supernumerary marker chromosome 15; TSC, tuberous sclerosis complex; XXY, Klinefelter syndrome.

ISSN: 2040-2392