PCA plot of ADI-R profiles of subjects in the genetic disorder sample, with the AGRE0 subsample inserted. PC2 is the dimension with the most differentiating contrast among the genetic disorder groups. AGRE0, on average, has negative values on PC1 and is around 0 on PC2. The TSC group (5) is also on average 0 on PC2 similar to AGRE0 and has the most negative average on PC1. Groups 1, 4 and 6 also display some closeness to AGRE0. Colors/numbers/letters denote genetic disorder subgroups. 1, 22q11.2 deletion syndrome; 2, Down’s syndrome; 3, Prader-Willi syndrome; 4, supernumerary marker chromosome 15, 5, tuberous sclerosis complex, 6, Klinefelter syndrome; A, AGRE0. ADI-R, Autism Diagnostic Interview-Revised; PCA, principal component analysis; TSC, tuberous sclerosis complex.