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Table 2 Correlation of Simons Foundation and Autism Research Initiative (SFARI) database genes with published transcriptome studies in Autism Spectrum Disorder (ASD) brain and our study

From: Transcriptome profiling in engrailed-2 mutant mice reveals common molecular pathways associated with autism spectrum disorders

Cerebellum # SFARI genes % enrichment P value Gene names
This study (3 En2-/-, 3 WT) 21 2.79% 4.98E-01 Ada, Ahi1 , Cacna1g , Cdh10, Eml1, Erbb4, Glo1, Gnas, Grm5, Itgb7, Kdm5c, Kit, Nrp2, Nrxn3, Park2, Pinx1, Plcb1, Rb1cc1, Rpp25, Stk39, Th
Voineagu et al.[9] (11 autism, 10 controls) 16 4.75% 3.43E-02 (*) AHI1 , ANK3, CACNA1G , CBS, EN2 , EPHB6, FAT1, FOXP1,GAP43, GRIN2A, HSD11B1, NLGN3, NTNG1, RAB11FIP5, SLC30A5, UBE3A
Purcell et al.[39] (9 autism, 9 controls) 1 3.33% 5.85E-01 CNR1
Limbic regions # SFARI genes % enrichment P value Gene names
This study (3 En2-/-, 3 WT) 33 4.24% 2.65E-02 (*) Aff4, Atp2b2 , Baiap2, Camta1, Dab1, Dctn5, Dlg4, Egr2, Eif4ebp2 , Ep400, Foxp1, Gabra4, Gnas, Gsk3b, Gtf2i, Kit, Klc2, Lrrc1, Nrcam, Ntng1, Ntrk3 , Park2, Plcb1, Prkcb , Rpp25 , Sbf1, Scn1a, Scn8a, Syn1, Syne1, Thra, Ube2h , Ubl7
Voineagu et al.[9] (13 autism, 13 controls) 36 3.70% 1.04E-01 AHI1 , APBA2, ATP2B2 , ATRNL1, AUTS2, BCL2, BTAF1, CADM1, CD99L2, DNM1L, DPP10, EIF4EBP2 , FAT1, GRIN2A, ICA1, MAOA, MSN , NTRK3 , PCDH9, PPFIA1, PRKCB , PTCHD1, RAB11FIP5, RGS7, RPP25 , SLC16A3, SLC25A12, SLC9A9, STXBP1, SYT17, TOMM20, TSC2, TUBGCP5, UBE2H , UBR5, UPF3B
Garbett et al.[40] (6 autism, 6 controls) 4 3.05% 5.52E-01 AHI1 , MSN , SDC2, SLC9A9
  1. Percentage of enrichment calculated on SFARI ASD-associated genes compared to the number of differentially expressed genes. Differentially expressed genes in Voineagu et al.[9] calculated using GEO2R analysis. Genes present in at least two of the studies are shown in bold. Enrichment P values calculated with the hypergeometric test, (*) P <0.05.