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Table 4 Significant SNPs and SNP-SNP pairs

From: Genetic variation in GABRB3 is associated with Asperger syndrome and multiple endophenotypes relevant to autism

SNP or SNP-SNP interaction

Phenotype

P values (uncorrected)a

Minor allele/major alleleb

MAF (HapMap CEPH)c

Frequency of minor allele

χ2

Cases

Controls

 

rs7180158

AS

3.58E-04

A/G

A = 0.24

0.1624

0.08272

12.74

rs7165604

AS

4.51E-04

C/T

C = 0.17

0.1174

0.05145

12.31

rs12593579

AS

6.68E-04

C/A

C = 0.21

0.194

0.1093

11.58

rs11636966

EQ

5.94E-04

T/C

T = 0.22

NA

NA

NA

rs9806546

EQ

1.47E-03

A/G

A = 0.40

NA

NA

NA

rs12438141-rs1035751

EFT

7.59E-06

C/T - A/G

T = 0.13, G = 0.06

NA

NA

NA

rs12438141-rs7179514

EFT

5.21E-06

C/T - C/G

T = 0.13, G = 0.31

NA

NA

NA

rs7174437-rs1863455

MRT

1.58E-05

C/T - C/T

C = 0.12, C = 0.08

NA

NA

NA

  1. Abbreviations: AQ, Autism Spectrum Quotient; AS, Asperger syndrome; EFT, Embedded Figures Test; EQ, Empathy Quotient; MRT, Mental Rotation Test; NA, not applicable; SNP, single nucleotide polymorphism.
  2. aCorrected P-value threshold is 3.6 × 10-05.
  3. bAlleles for SNP-SNP pairs have been provided in the order they are written.
  4. cMAF for SNP-SNP pairs have been provided in the order they are written.