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Table 2 GABRB3 SNP association results for AS and the six quantitative endophenotypes investigated

From: Genetic variation in GABRB3 is associated with Asperger syndrome and multiple endophenotypes relevant to autism

SNP

SNP position

AS case–control

P value

  

OR

P value

AQ

EQ

SQ-R

EFT

REMT

MRT

rs2114485

26802824

0.9369

0.704

0.6105

0.6514

0.6369

0.6719

0.1518

0.9454

rs11631940

26806814

0.8902

0.5088

0.6759

0.8435

0.1997

0.8645

0.8271

0.4787

rs1432007

26810689

1.127

0.4205

0.7813

0.6526

0.5193

0.7481

0.2376

0.7725

rs1426217

26821125

1.082

0.5975

0.439

0.4008

0.5922

0.5827

0.6484

0.5826

rs10519563

26823404

1.096

0.6204

0.8042

0.1096

0.1448

0.3941

0.9824

0.2969

rs12440905

26826281

1.584

0.3943

0.9656

0.2318

0.9096

0.5663

0.6207

0.5445

rs17646555

26837651

1.089

0.749

0.7359

0.0351

0.7584

0.6143

0.2616

0.1865

rs12437672

26838405

1.016

0.9246

0.6538

0.3636

0.4328

0.8751

0.675

0.4629

rs1582760

26853487

1.114

0.6609

0.902

0.2335

0.7375

0.4951

0.4093

0.3209

rs2873027

26867409

0.9804

0.8947

0.4164

0.7438

0.4436

0.3401

0.996

0.7369

rs12438141

26870602

1.094

0.6625

0.2593

0.05641

0.7694

0.04683

0.1429

0.004928

rs10873636

26888978

0.8377

0.2985

0.01893a

0.01765a

0.04946a

0.8912

0.05818

0.02446

rs11636966

26893028

0.9915

0.9547

0.06219

0.000594a

0.8307

0.7713

0.5205

0.7296

rs9806546

26893386

0.7572

0.188

0.06427

0.001469

0.009834a

0.6132

0.4449

0.3145

rs8023959

26894305

1.034

0.887

0.1065

0.7408

0.8473

0.3852

0.05979

0.06356

rs7179514

26895324

1.028

0.8525

0.107

0.002318a

0.5474

0.3509

0.5521

0.1739

rs7171512

26906345

0.9611

0.7976

0.3705

0.01302a

0.3096

0.7664

0.1414

0.9829

rs12442889

26917100

1.041

0.8066

0.3348

0.2381

0.3188

0.8606

0.6945

0.1025

rs1367959

26917158

1.178

0.315

0.7905

0.001742a

0.1215

0.02745

0.2206

0.05204

rs1863455

26918169

0.8474

0.4769

0.2206

0.5058

0.4483

0.3591

0.005442

0.8047

rs890317

26922201

0.8293

0.2741

0.9942

0.1927

0.9031

0.09281

0.887

0.8351

rs11161329

26926710

0.8283

0.2203

0.5383

0.07182

0.6331

0.02263

0.07253

0.7137

rs12593482

26933545

1.119

0.7621

0.7125

0.04769a

0.2482

0.6505

0.9041

0.6601

rs1035751

26943796

0.8033

0.4228

0.531

0.8884

0.9924

0.1161

0.9053

0.4785

rs7181473

26950087

1.018

0.9072

0.4267

0.5739

0.9399

0.7201

0.8816

0.6508

rs17117279

26952672

0.8777

0.5218

0.3016

0.09375

0.6948

0.1173

0.2397

0.4522

rs1426224

26953091

0.984

0.9632

0.3725

0.1801

0.2826

0.5186

0.1248

0.4864

rs1549482

26953764

1.073

0.7015

0.9659

0.6341

0.6026

0.072

0.4522

0.3501

rs4906896

26960426

1.354

0.04067a

0.001682a

0.01946a

0.8831

0.05366

0.03463a

0.126

rs737098

26967170

0.7071

0.04886a

0.1189

0.1006

0.03769a

0.9156

0.5102

0.6054

rs2315904

26967522

0.8293

0.4539

0.4212

0.5888

0.08328

0.1348

0.3303

0.1788

rs1863456

26974032

1.006

0.9703

0.116

0.06622

0.7006

0.2814

0.6925

0.271

rs2162241

26976782

0.7075

0.02707a

0.2351

0.1778

0.2413

0.5519

0.5273

0.8923

rs7180158b

26978238

2.15

0.000358a

0.4416

0.2842

0.01907a

0.3974

0.7486

0.124

rs8026932b

26978906

1.263

0.5769

0.006922a

0.9863

0.7881

0.6083

0.1999

0.9726

rs6576602b

26982080

1.46

0.03347a

0.189

0.3375

0.00998a

0.05174

0.4184

0.01776a

rs890318b

26982378

0.745

0.2896

0.2458

0.8865

0.3377

0.08322

0.4733

0.1141

rs12593579b

26988132

1.96

0.000668a

0.5066

0.335

0.03631a

0.3711

0.74

0.2056

rs8038471b

26990651

1.154

0.3372

0.08613

0.01078a

0.9937

0.3891

0.8799

0.6707

rs12905535b

26992166

0.6169

0.005747a

0.08597

0.03931a

0.04997a

0.283

0.4318

0.07415

rs7165604b

26994456

2.452

0.000451a

0.1189

0.1297

0.1982

0.278

0.8782

0.09043

rs7174437b

26997923

2.022

0.01567a

0.1185

0.02142a

0.5118

0.4765

0.8321

0.4211

rs7178713

27002886

0.6789

0.01877a

0.4842

0.1292

0.1468

0.5308

0.1201

0.1008

rs8026392

27008723

0.8825

0.4244

0.05513

0.02792a

0.4595

0.4105

0.6825

0.3217

rs3212331

27014769

0.896

0.53

0.6579

0.7116

0.6821

0.2821

0.8648

0.5415

  1. Abbreviations: AQ Autism Spectrum Quotient, EFT Embedded Figures Test, EQ Empathy Quotient, MRT Mental Rotation Test, RMET Reading the Mind in the Eyes Test, SQ-R Systemizing Quotient, Revised, SNP single nucleotide polymorphism.
  2. aNominally significant P-values (P < 0.05).
  3. bSNPs found in haplotype block 7 (as referred to in Figure 2).