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Figure 7 | Molecular Autism

Figure 7

From: Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells

Figure 7

Correlation analysis between DNA methylation at the Methyl CpG binding protein 2 gene ( Mecp2 ) regulatory elements and Mecp2 expression after decitabine treatment (day 2) and decitabine withdrawal (day 8). All graphs represent the Pearson's correlation coefficient (r) for Mecp2e1 (black), and Mecp2e2 (pink): statistical significance: ***P <0.001; **P <0.01; *P <0.05; n = 3. (A) Correlation coefficients for the relation between Mecp2 expression and average methylation over entire regions in Mecp2 promoter (region (R)1 to R3) and intron 1 (R4 to R6) after decitabine exposure on day 2 (D2) (a), and after decitabine withdrawal on D8 (b). (B) After decitabine exposure: correlation coefficients for Mecp2e1 (black), and Mecp2e2 (pink) with individual CpG methylation at the promoter regions (a) R1, (b) R2 and (c) R3, and intron 1 regions (d) R4, (e) R5 and (f) R6. (C) After decitabine withdrawal: correlation coefficients for Mecp2e1 (black), and Mecp2e2 (pink) with individual CpG methylation at promoter regions (a) R1, (b) R2 and (c) R3, and intron 1 regions (d) R4, (e) R5 and (f) R6. Statistical significance: *P <0.05; n = 3.

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