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Table 5 Ingenuity pathways that were significantly enriched in multiple ASD short-hairpin (sh)RNA knockdown experiments

From: Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action

Description Blank pathway ranking Fmr1 pathway ranking Mef2a pathway ranking Mef2d pathway ranking Mecp2 pathway ranking Nlgn1 pathway ranking Nlgn3 pathway ranking Pten pathway ranking Shank3 pathway ranking Pathway count Average ranking
Axonal guidance signaling 4 1 16 2 1 2 1 4 1 8 3.50
Molecular mechanisms of cancer 6 5 2 11 6 1 2 1 6 8 4.25
Breast cancer regulation by stathmin1 13 8 1 8 4 3 5 2   7 4.43
G-protein coupled receptor signaling   2 10 5 8    9   5 6.80
Protein kinase A signaling   6   18 2   14 3   5 8.60
Huntington’s disease signaling    23 1 37    22 3 5 17.20
Corticotropin-releasing hormone signaling    4 9 31   7 36   5 17.40
Calcium signaling 8   15 12 44    43 11 5 25.00
Amyotrophic lateral sclerosis signaling   4   15 66    41 7 5 26.60
Synaptic long-term potentiation    5 6 5    6   4 5.50
cAMP-mediated signaling    8 7 3    7   4 6.25
GNRH signaling    6 20 9    13   4 12.00
Neuropathic pain signaling in dorsal horn neurons   7 21 3     18   4 12.25
Neuroprotective role of THOP1 in Alzheimer’s disease 7 23 19    4 6    4 13.00
Role of NFAT in cardiac hypertrophy     17 7   9 19   4 13.00