Table 5 Ingenuity pathways that were significantly enriched in multiple ASD short-hairpin (sh)RNA knockdown experiments
Description | Blank pathway ranking | Fmr1 pathway ranking | Mef2a pathway ranking | Mef2d pathway ranking | Mecp2 pathway ranking | Nlgn1 pathway ranking | Nlgn3 pathway ranking | Pten pathway ranking | Shank3 pathway ranking | Pathway count | Average ranking |
|---|---|---|---|---|---|---|---|---|---|---|---|
Axonal guidance signaling | 4 | 1 | 16 | 2 | 1 | 2 | 1 | 4 | 1 | 8 | 3.50 |
Molecular mechanisms of cancer | 6 | 5 | 2 | 11 | 6 | 1 | 2 | 1 | 6 | 8 | 4.25 |
Breast cancer regulation by stathmin1 | 13 | 8 | 1 | 8 | 4 | 3 | 5 | 2 | Â | 7 | 4.43 |
G-protein coupled receptor signaling | Â | 2 | 10 | 5 | 8 | Â | Â | 9 | Â | 5 | 6.80 |
Protein kinase A signaling | Â | 6 | Â | 18 | 2 | Â | 14 | 3 | Â | 5 | 8.60 |
Huntington’s disease signaling |  |  | 23 | 1 | 37 |  |  | 22 | 3 | 5 | 17.20 |
Corticotropin-releasing hormone signaling | Â | Â | 4 | 9 | 31 | Â | 7 | 36 | Â | 5 | 17.40 |
Calcium signaling | 8 | Â | 15 | 12 | 44 | Â | Â | 43 | 11 | 5 | 25.00 |
Amyotrophic lateral sclerosis signaling | Â | 4 | Â | 15 | 66 | Â | Â | 41 | 7 | 5 | 26.60 |
Synaptic long-term potentiation | Â | Â | 5 | 6 | 5 | Â | Â | 6 | Â | 4 | 5.50 |
cAMP-mediated signaling | Â | Â | 8 | 7 | 3 | Â | Â | 7 | Â | 4 | 6.25 |
GNRH signaling | Â | Â | 6 | 20 | 9 | Â | Â | 13 | Â | 4 | 12.00 |
Neuropathic pain signaling in dorsal horn neurons | Â | 7 | 21 | 3 | Â | Â | Â | 18 | Â | 4 | 12.25 |
Neuroprotective role of THOP1 in Alzheimer’s disease | 7 | 23 | 19 |  |  | 4 | 6 |  |  | 4 | 13.00 |
Role of NFAT in cardiac hypertrophy | Â | Â | Â | 17 | 7 | Â | 9 | 19 | Â | 4 | 13.00 |