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Table 4 Canonical pathways in NextBio that were significantly enriched following ASD gene-targeted shRNA constructs, but not affected by luciferase shRNA

From: Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action

  ASD gene count Fmr1 Mecp2 Mef2a Mef2d Nlgn1 Nlgn3 Pten Shank3
Biogroup   Up Down Up Down Up Down Up down Up Down Up Down Up Down Up Down
TrkA receptor 8   2   4   2   2   2   3 3    2
Erythropoietin-mediated neuroprotection through NFKB 7 3 2   3   3   1   2   1 3    
PGC1A pathway 7     8   5   7   3   4   9   4
Long-term potentiation 7 8    18   5   15 3      16   6
Cell adhesion molecules (CAMs) 7    10 14   8   13   8   11 13 12   10
G2 and M phases 7   1   1   1 1 1   1   2 3    
P53 HYPOXIA pathway 7   3   3   3   3   2   3 6    
Biosynthesis of steroids 6   8   5     3 2    5   4   
Arginine and proline metabolism 6   8   9 1    8     8 5    
Antigen processing and presentation 6     9   3   6   3   10     4
BAD pathway 6   3     3   4 2   2      2
Neuroregulin receptor degredation protein-1 controls ERBB3 receptor recycling 6    1   1   1   1   1     1  
Eicosanoid synthesis 6       1   1   1   1 3    2
Phosphatidylinositol signaling system 5 10    17       6   11   10   
Vitamin B6 metabolism 5 1    3    1 1    1 2   1