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Table 3 Autism spectrum disorder interactome genes significantly altered by three or more shRNA treatments

From: Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action

Gene Gene description Fold-change
   Fmr1 Mecp2 Mef2a Mef2d Nlgn1 Nlgn3 Pten Shank3
Camk2a Calcium/calmodulin-dependent protein kinase II alpha 1.69 −2.00 −1.81 −1.65 −1.85 −1.68 −2.53 −1.68
Prmt1 Protein arginine N-methyltransferase 1 1.55 2.32   2.02 1.65 2.17 1.79 2.06
Cacna1c Calcium channel, voltage-dependent, L-type, alpha 1C subunit 1.68 1.75 1.69 1.90 1.64 1.67 2.23  
Sh3gl3 SH3-domain GRB2-like 3   1.59 1.70 1.62 1.59 1.63 1.84 1.56
R3hdm1 R3H domain 1 (binds single-stranded nucleic acids) 2.40 −2.09 −1.63 1.92   −1.65 −1.88  
Tgfb1i1 Transforming growth factor beta 1-induced transcript 1     −2.96 1.74 −3.19 2.48  
Lims2 LIM and senescent cell antigen-like domains 2   2.43   1.75    3.80 1.90
Kif17 Kinesin family member 17 −2.01 −2.13   −2.36   −1.70   
Nkd2 Naked cuticle 2 homolog (Drosophila) −1.78 −2.12   −1.83   −1.77   
Capn3 Calpain 3   −1.65 1.53 2.98    −1.77  
Nell1 NEL-like 1 (chicken) 2.23 −1.85   −1.58 1.64    
PYCR1 Pyrroline-5-carboxylate reductase 1 −1.56 −2.81     −2.00 1.55  
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 1.94 −2.08 1.57     1.50  
Prr13 Proline-rich 13 −1.81 −1.77   −1.71   −1.82   
STK32C Serine/threonine kinase 32C   −1.89     −1.64 −1.69 −1.51
DLGAP2 Discs, large (Drosophila) homolog-associated protein 2 1.80   −1.60   −2.10    
SOD1 Superoxide dismutase 1, soluble    −1.64     −2.22 −1.69
Dlgap1 Discs, large (Drosophila) homolog-associated protein 1 1.91    −2.45    −1.86  
MBD2 Methyl-CpG binding domain protein 2    −1.94    −1.58   −1.55
FBLN5 Fibulin 5 1.52 2.15      2.69  
Sertad1 SERTA domain-containing 1     −1.67   −1.95   −1.69
Bhlhe40 Basic helix-loop-helix family, member e40   −2.28   −1.85   −1.74   
Slit2 Slit homolog 2 (Drosophila)   −1.68   −2.43    −2.09  
Actn2 Actinin alpha 2   −2.64   −1.53   −1.65   
Ube3a Ubiquitin protein ligase E3A   −2.48   −1.52     −1.53
Slc13a3 Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3     2.32   1.56 −1.60  
NOMO1 NODAL modulator 1    1.64     1.53 1.54
RALBP1 RalA binding protein 1 1.65   1.52     1.73  
MYH10 Myosin, heavy chain 10, non-muscle −2.12 −1.78      −1.53  
HMG20A High-mobility group 20A   1.68 1.59     1.76  
BAIAP2 BAI1-associated protein 2      −1.51 −1.73 −1.55  
Fxr1 Fragile X mental retardation gene 1, autosomal homolog 1.61 1.56   1.99     
Lingo1 Leucine-rich repeat and Ig domain-containing 1     −1.56    −1.73 −1.57
Nup62 Nucleoporin 62 −1.54    −1.59   −1.70   
Notch2 Notch gene homolog 2 (Drosophila)   1.69   1.52    −2.06  
EML1 Echinoderm microtubule-associated protein-like 1 −1.64 1.72      −1.72  
NECAB3 N-terminal EF-hand calcium-binding protein 3   −1.79     −1.52 −1.75  
Tcf25 Transcription factor 25 (basic helix-loop-helix)     −1.51   −1.69 −1.54