Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action

Lanz, Thomas A; Guilmette, Edward; Gosink, Mark M; Fischer, James E; Fitzgerald, Lawrence W; Stephenson, Diane T; Pletcher, Mathew T

doi:10.1186/2040-2392-4-45

Molecular Autism

Table 3 Autism spectrum disorder interactome genes significantly altered by three or more shRNA treatments

From: Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action

Gene	Gene description	Fold-change
		Fmr1	Mecp2	Mef2a	Mef2d	Nlgn1	Nlgn3	Pten	Shank3
Camk2a	Calcium/calmodulin-dependent protein kinase II alpha	1.69	−2.00	−1.81	−1.65	−1.85	−1.68	−2.53	−1.68
Prmt1	Protein arginine N-methyltransferase 1	1.55	2.32		2.02	1.65	2.17	1.79	2.06
Cacna1c	Calcium channel, voltage-dependent, L-type, alpha 1C subunit	1.68	1.75	1.69	1.90	1.64	1.67	2.23
Sh3gl3	SH3-domain GRB2-like 3		1.59	1.70	1.62	1.59	1.63	1.84	1.56
R3hdm1	R3H domain 1 (binds single-stranded nucleic acids)	2.40	−2.09	−1.63	1.92		−1.65	−1.88
Tgfb1i1	Transforming growth factor beta 1-induced transcript 1				−2.96	1.74	−3.19	2.48
Lims2	LIM and senescent cell antigen-like domains 2		2.43		1.75			3.80	1.90
Kif17	Kinesin family member 17	−2.01	−2.13		−2.36		−1.70
Nkd2	Naked cuticle 2 homolog (Drosophila)	−1.78	−2.12		−1.83		−1.77
Capn3	Calpain 3		−1.65	1.53	2.98			−1.77
Nell1	NEL-like 1 (chicken)	2.23	−1.85		−1.58	1.64
PYCR1	Pyrroline-5-carboxylate reductase 1	−1.56	−2.81				−2.00	1.55
TBC1D9B	TBC1 domain family, member 9B (with GRAM domain)	1.94	−2.08	1.57				1.50
Prr13	Proline-rich 13	−1.81	−1.77		−1.71		−1.82
STK32C	Serine/threonine kinase 32C		−1.89				−1.64	−1.69	−1.51
DLGAP2	Discs, large (Drosophila) homolog-associated protein 2	1.80		−1.60		−2.10
SOD1	Superoxide dismutase 1, soluble			−1.64				−2.22	−1.69
Dlgap1	Discs, large (Drosophila) homolog-associated protein 1	1.91			−2.45			−1.86
MBD2	Methyl-CpG binding domain protein 2			−1.94			−1.58		−1.55
FBLN5	Fibulin 5	1.52	2.15					2.69
Sertad1	SERTA domain-containing 1				−1.67		−1.95		−1.69
Bhlhe40	Basic helix-loop-helix family, member e40		−2.28		−1.85		−1.74
Slit2	Slit homolog 2 (Drosophila)		−1.68		−2.43			−2.09
Actn2	Actinin alpha 2		−2.64		−1.53		−1.65
Ube3a	Ubiquitin protein ligase E3A		−2.48		−1.52				−1.53
Slc13a3	Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3				2.32		1.56	−1.60
NOMO1	NODAL modulator 1			1.64				1.53	1.54
RALBP1	RalA binding protein 1	1.65		1.52				1.73
MYH10	Myosin, heavy chain 10, non-muscle	−2.12	−1.78					−1.53
HMG20A	High-mobility group 20A		1.68	1.59				1.76
BAIAP2	BAI1-associated protein 2					−1.51	−1.73	−1.55
Fxr1	Fragile X mental retardation gene 1, autosomal homolog	1.61	1.56		1.99
Lingo1	Leucine-rich repeat and Ig domain-containing 1				−1.56			−1.73	−1.57
Nup62	Nucleoporin 62	−1.54			−1.59		−1.70
Notch2	Notch gene homolog 2 (Drosophila)		1.69		1.52			−2.06
EML1	Echinoderm microtubule-associated protein-like 1	−1.64	1.72					−1.72
NECAB3	N-terminal EF-hand calcium-binding protein 3		−1.79				−1.52	−1.75
Tcf25	Transcription factor 25 (basic helix-loop-helix)				−1.51		−1.69	−1.54

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ISSN: 2040-2392

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