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Table 1 Description of genes selected for short-hairpin (sh)RNA knockdown and linkage to ASD

From: Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action

Gene Function Cellular localization Genetic evidence Reference
Methyl CpG binding protein 2 (Mecp2) Transcriptional repressor Nuclear Causes Rett syndrome, which shares some symptom domains with autism [37]
Myocyte-specific enhancer factor 2a (Mef2a) Transcription factor Nuclear Rare single gene mutation in downstream targets associated with Autism symptom domains [32]
Myocyte-specific enhancer factor 2d (Mef2d) Transcription factor Nuclear Rare single gene mutation in downstream targets associated with Autism symptom domains [32]
Fragile X mental retardation 1 (Fmr1) RNA binding protein Nuclear Causes Fragile X, which shares some symptom domains with autism [38]
Neuroligin-1 (Nlgn1) Synaptic remodeling Synaptic Rare single gene mutation associated with autism symptom domains [30]
Neuroligin-3 (Nlgn3) Synaptic remodeling Synaptic Rare single gene mutation associated with autism symptom domains [31]
Phosphatase and tensin homolog (Pten) Regulator of the cell cycle Nuclear and synaptic Causes Cowden syndrome which shares some symptom domains with autism [26, 39]
SH3 and multiple ankyrin repeat domains 3 (Shank3) Scaffold protein Synaptic Rare single gene mutation associated with autism symptom domains [12, 29]