Figure 1From: Platelets of mice heterozygous for neurobeachin, a candidate gene for autism spectrum disorder, display protein changes related to aberrant protein kinase A activityReduced total surface area of dense granules due to a decrease in surface area of the halo in platelets of Nbea+/-mice. (A) Electron microscopic view of a blood platelet of Nbea+/+ and Nbea+/- mice. Dense granules are indicated with black arrows. (B) Distribution of dense granule number according to their surface area. Dense granules of platelets of Nbea+/- mice were significantly smaller than dense granules of platelets of Nbea+/+ mice (n = 200 platelets/genotype).Back to article page