Common variation contributes to the genetic architecture of social communication traits

Table 3 Association results for the lead signals from the discovery analysis

			Nearest	Discovery (N = 5,584)			Replication (N = 1,364)			Combined (N = 6,948)
SNP	Chr	E,A	Gene	EAF	β (SE)^a	P ^a	EAF	β (SE)	P	β (SE)	P	Het-P
rs761490	1p32.3	C,G	TMEM48	0.24	0.096 (0.022)	9.7E-06	0.23	−0.051 (0.090)	0.57	0.088 (0.021)	3.0E-05	0.11
rs9257616	6p22.1	G,A	*OR2J2*	0.56	0.086 (0.018)	3.1E-06	0.54	0.19 (0.074)	0.009	0.093 (0.018)	2.5E-07	0.16
rs12115663	9p22.3	C,A	BNC2	0.86	0.13 (0.027)	4.1E-06	0.87	−0.12 (0.10)	0.23	0.11 (0.026)	3.6E-05	0.018
rs1834180	10q25.1	A,G	intergenic	0.68	0.10 (0.020)	3.3E-07	0.70	0.033 (0.079)	0.68	0.097 (0.019)	4.6E-07	0.40
rs2352908	14q22.1	G,T	intergenic	0.84	0.11 (0.026)	8.2E-06	0.83	0.24 (0.10)	0.022	0.12 (0.025)	1.1E-06	0.25
rs11625667	14q24.3	G,A	TMEM90A	0.36	0.085 (0.018)	4.3E-06	0.35	−0.049 (0.076)	0.52	0.077 (0.018)	1.7E-05	0.086
rs4218	15q22.2	G,C	MYO1E	0.29	0.11 (0.020)	2.6E-08	0.31	−0.027 (0.080)	0.74	0.10 (0.019)	1.0E-07	0.096

^a - Genomic-control corrected.
Results are presented for the most significant signals (Genomic-control corrected P ≤1E-05) from independent loci during the discovery stage of the analysis. Regression estimates were obtained using Quasi-Poisson regression. All SNPs were imputed and had an imputation quality of 0.90 <R² ≤0.99 (MACH); Replicated signals are indicated in bold. E, Effect allele; A, Alternative allele; EAF, Effect allele frequency; Het-P, Heterogeneity P- value.

ISSN: 2040-2392