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Table 3 Association results for the lead signals from the discovery analysis

From: Common variation contributes to the genetic architecture of social communication traits

  Nearest Discovery (N = 5,584) Replication (N = 1,364) Combined (N = 6,948)
SNP Chr E,A Gene EAF β (SE)a P a EAF β (SE) P β (SE) P Het-P
rs761490 1p32.3 C,G TMEM48 0.24 0.096 (0.022) 9.7E-06 0.23 −0.051 (0.090) 0.57 0.088 (0.021) 3.0E-05 0.11
rs9257616 6p22.1 G,A OR2J2 0.56 0.086 (0.018) 3.1E-06 0.54 0.19 (0.074) 0.009 0.093 (0.018) 2.5E-07 0.16
rs12115663 9p22.3 C,A BNC2 0.86 0.13 (0.027) 4.1E-06 0.87 −0.12 (0.10) 0.23 0.11 (0.026) 3.6E-05 0.018
rs1834180 10q25.1 A,G intergenic 0.68 0.10 (0.020) 3.3E-07 0.70 0.033 (0.079) 0.68 0.097 (0.019) 4.6E-07 0.40
rs2352908 14q22.1 G,T intergenic 0.84 0.11 (0.026) 8.2E-06 0.83 0.24 (0.10) 0.022 0.12 (0.025) 1.1E-06 0.25
rs11625667 14q24.3 G,A TMEM90A 0.36 0.085 (0.018) 4.3E-06 0.35 −0.049 (0.076) 0.52 0.077 (0.018) 1.7E-05 0.086
rs4218 15q22.2 G,C MYO1E 0.29 0.11 (0.020) 2.6E-08 0.31 −0.027 (0.080) 0.74 0.10 (0.019) 1.0E-07 0.096
  1. a - Genomic-control corrected.
  2. Results are presented for the most significant signals (Genomic-control corrected P ≤1E-05) from independent loci during the discovery stage of the analysis. Regression estimates were obtained using Quasi-Poisson regression. All SNPs were imputed and had an imputation quality of 0.90 <R2 ≤0.99 (MACH); Replicated signals are indicated in bold. E, Effect allele; A, Alternative allele; EAF, Effect allele frequency; Het-P, Heterogeneity P- value.