Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders

Table 3 Multiplex immunoassay analysis identification of proteins with significant age-diagnosis interactions

Analytes	Interaction P value	Fold change^a
		<9 years	9 to 13 years	>13 years
Haptoglobin (HP)	0.021	0.36	1.20	2.83
Cancer antigen 19–9 (CA-19-9)	0.046	0.59	1.17	2.45
Thyroglobulin (TG)	0.021	0.32	1.35	2.39
C-Reactive Protein (CRP)	0.014	0.51	1.90	2.35
TRAIL-R3 (TR3)	0.034	0.86	0.81	1.31
Adiponectin (ADIP)	0.007	0.80	0.81	1.25
Matrix metalloproteinase 7 (MMP-7)	0.005	0.82	1.07	1.23
Interferon inducible T cell α chemoattractant (ITAC)	0.035	0.66	0.86	1.21
Insulin-like growth factor binding protein 5 (IGFBP5)	0.027	1.23	0.95	0.87
Transferrin (TF)	0.012	1.28	0.89	0.86
Neuropilin-1 (NP1)	0.020	1.24	0.92	0.83
Creatine kinase-MB (CK-MB)	0.022	1.50	0.94	0.83

^aThe data obtained for all subjects were partitioned into the indicated age bins and geometric means were used to calculate fold changes (autism spectrum disorder/control).