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Table 3 Multiplex immunoassay analysis identification of proteins with significant age-diagnosis interactions

From: Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders

Analytes Interaction P value Fold changea
   <9 years 9 to 13 years >13 years
Haptoglobin (HP) 0.021 0.36 1.20 2.83
Cancer antigen 19–9 (CA-19-9) 0.046 0.59 1.17 2.45
Thyroglobulin (TG) 0.021 0.32 1.35 2.39
C-Reactive Protein (CRP) 0.014 0.51 1.90 2.35
TRAIL-R3 (TR3) 0.034 0.86 0.81 1.31
Adiponectin (ADIP) 0.007 0.80 0.81 1.25
Matrix metalloproteinase 7 (MMP-7) 0.005 0.82 1.07 1.23
Interferon inducible T cell α chemoattractant (ITAC) 0.035 0.66 0.86 1.21
Insulin-like growth factor binding protein 5 (IGFBP5) 0.027 1.23 0.95 0.87
Transferrin (TF) 0.012 1.28 0.89 0.86
Neuropilin-1 (NP1) 0.020 1.24 0.92 0.83
Creatine kinase-MB (CK-MB) 0.022 1.50 0.94 0.83
  1. aThe data obtained for all subjects were partitioned into the indicated age bins and geometric means were used to calculate fold changes (autism spectrum disorder/control).