Demographic character | Methodological character | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Study | ASD | TD | Value | Multiple comparison correction | ||||||||||||||||||||||||
N a | Males | Mean age (years) | IQb | N c | Males | Mean age (years) | IQb | Diagnostic tools | Medication / comorbidity | Tesla | B factor | Number of direction | NEX | TE/TR (ms) | Type of WBA | Software | FA | MD | RD | AD | ADC | Threshold | FWE | FDR | TFCE | Permutation | Main results | |
Whole brain voxel-wise analysis study | ||||||||||||||||||||||||||||
Ameis and colleagues [43] | 19 | 16 | 12.4 | 99 | 16 | 8 | 12.3 | 101 | DSM-IV/ADI-R/ADOs | No/No | 3 | 1,250 | 12 | 5 | 80/4,100 | TBSS | FSL4.1 | ○ | ○ | ○ | ○ | ○ | P <0.05 | ○ | × | ○ | × | MD↓ in UF, IFOF, CC, SLF, in ASD children |
Barnea-Goraly and colleagues [44] | 7 | 7 | 14.6 | 101 | 9 | 9 | 13.4 | 107 | ADI-R/ADOS | NA/Na | 3 | 900 | 6 | 4 | 106/6,000 | Voxel Based Whole Brain | SPM99 | ○ | × | × | × | × | P <0.05 | × | × | × | × | FA↓ in Cg, UF, in ASD |
Barnea-Goraly and colleagues [18] | 13 | 11 | 10.5 | 86 | 11 | 9 | 9.6 | 120 | ADI-R/ADOS | NA/No | 1.5 | 900 | 6 | 4 | 106/6,000 | TBSS | FSL4.1 | ○ | × | ○ | ○ | × | P <0.05 | ○ | × | ○ | ○ | FA↓ in CC, SLF, in ASD |
Bloemen and colleagues [45] | 13 | 113 | 39 | 110 | 13 | 13 | 37 | 115 | ICD-10/ADI-R/ADOS | NA/No | NA | 1,300 | 4 | NA | 107/15,000 | Voxel Based Whole Brain | SPM2 | ○ | ○ | ○ | × | × | P <0.05 | NA | NA | × | ○ | FA↓ in IFOF, ILF, CC, SLF, Cg, in ASD |
Bode and colleagues [46] | 27 | 20 | 14.7 | NA | 26 | 17 | 14.5 | NA | ADI-R/ADOS | NA/No | NA | 100 | NA | 1 | 90/8,000 | TBSS | FSL | ○ | ○ | × | × | × | P <0.0005 | NA | NA | × | × | FA↓ in IFOF |
Cheung and colleagues [48] | 13 | 12 | 9.3 | 100 | 14 | 13 | 9.9 | 112 | ICD-10/ADI-R | No/No | 1.5 | 1,200 | 25 | NA | 100/10,000 | Voxel Based Whole Brain | SPM2 | ○ | × | × | × | × | P <0.0005 | × | × | × | × | FA↓ in SLF, FA, in ASD |
Groen and colleagues [49] | 17 | 14 | 14.4 | 98 | 25 | 22 | 15.5 | 105 | ADI-R | No/No | 1.5 | 900 | 30 | 4 | 93/10,100 | Voxel Based Whole Brain | SPM5 | ○ | ○ | × | × | × | P <0.05 | × | ○ | × | × | FA↓ in SLF, ILF, in ASD |
Jeong and colleagues [50] | 32 | 29 | 439 | NA | 14 | 11 | 5.61 | NA | DSM-IV | NA/No | 3 | 1,000 | 6 | 6 | NA/1,250 | Whole Brain Tractography | FSL | ○ | ○ | × | × | × | Various | × | ○ | × | × | FA↓ in, AF <UF, CC in ASD |
Jou and colleagues [51] | 15 | 15 | 10.9 | NA | 8 | 8 | 11.5 | NA | DSM-IV/ADI-ADOS | NA/NA | 3 | NA | 30 | 3 | 85/6,200 | TBSS | FSL | ○ | × | ○ | ○ | × | P <0.05 | NA | NA | ○ | × | FA↓ in IFOF, SLF, UF, Cg, in ASD |
Jou and colleagues [52] | 10 | 10 | 13.5 | 91 | 10 | 10 | 13.5 | 105 | DSM-IV/ADI-R/ADOS | NA/NA | 1.5 | 1,000 | 6 | 6 | 92/1,1200 | Voxel Based Whole Brain | Biolmage Suite | ○ | × | × | × | × | p<0.05 | × | × | × | × | FA↓ in CC, CG, SLF, IFOF, ILF, in ASD |
Ke and colleagues [53] | 12 | 12 | 8375 | 101 | 12 | 12 | 9.4 | 100 | DSM-IV/ADI-R | NA/No | 1.5 | 1,000 | 15 | 2 | 104.4/8,000 | Voxel Based Whole Brain | SPMS | ○ | × | × | × | × | p<0.05 | × | × | × | × | No peak coordinates reported in cortical fibers |
Kumar and colleagues [26] | 32 | 29 | 5 | NA | 16 | 12 | 5.5 | NA | DSM-IV | NA/No | 3 | 1,000 | 6 | 6 | 79/1,0000 | TBSS | FSL | ○ | × | × | × | ○ | p<0.05 | × | × | × | × | FA↓ in rt UF, IFO, AF, rt Cg, CC in ASD |
Noriuchi and colleagues [54] | 7 | 6 | 14 | 93 | 7 | 6 | 13.4 | 116 | DSM-IV | NA/NA | 3 | 800 | 32 | NA | 88/7,420 | Voxel Based Whole Brain | SPM2 | ○ | × | × | × | × | p<0.05 | ○ | × | × | × | FA↓ in SLF, CC, Cg, in ASD |
Sahyoun and colleagues [55] | 12 | 9 | 12.8 | 101 | 12 | 9 | 13.3 | 106 | DSM-IV/ADI-R | No/NA | 3 | 700 | 60 | NA | 84/7,980 | TBSS | FSL | ○ | ○ | × | × | × | p<0.05 | NA | NA | × | ○ | FA↑ in bl UF, rt SLF, FA↓ in bl, SLF, bl FOF in ASD |
Thakkar and colleagues [56] | 12 | 10 | 30 | 116 | 14 | 8 | 27 | 114 | DSM-IV/ADI-R/ADOS | Yes/No | 3 | 700 | 60 | NA | 82/8,400 | Voxel Based Whole Brain | FSL | ○ | × | × | × | × | p<0.05 | NA | NA | × | × | FA↓ in Cg in ASO |
Weinstein and colleagues [27] | 21 | NA | 3.3 | NA | 26 | NA | 3.3 | NA | DSM-IV/ADI-R/ADOS | NA/No | 1.5 | 1,000 | 15 | 2 | 94/1,1000 | TBSS | FSL 0 | ○ | ○ | ○ | ○ | × | p<0.05 | NA | NA | ○ | × | FA↑ in lt SLF, bl Cg, CC in ASD |