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Figure 5 | Molecular Autism

Figure 5

From: Non-synonymous single-nucleotide variations of the human oxytocin receptor gene and autism spectrum disorders: a case–control study in a Japanese population and functional analysis

Figure 5

Agonist-induced IP 3 accumulation. Average time courses of changes in IP3 accumulation elicited with 100 nM OXT; IP3 levels were measured in HEK293 cells expressing hOXTR-376R-EGFP, hOXTR-376G-EGFP, and hOXTR-376C-EGFP. Data are expressed as mean ± standard error of the mean (n = 13 to 15 cultures from five independent experiments). During the initial 5 to 30 s after OXT application, a significant drop from the maximum IP3 levels was observed in these cells (P = 0.0210, F(1, 107) = 5.49 for hOXTR-376G-EGFP; P = 0.0209, F(1, 103) = 5.5 for hOXTR-376C-EGFP; compared with the values for hOXTR-376R-EGFP; two-way ANOVA).

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Molecular Autism

ISSN: 2040-2392