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Table 1 Demographic data for individuals with autism and controls

From: Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase, and homer 1, in autism: a postmortem study in cerebellar vermis and superior frontal cortex

Case Dx Sex Age PMI (hrs) Ethnicity Medication history Cause of death Seizure ID Side of brain Brain region
UMB-4670 Control M 4 17 Caucasian None Commotio cordis No No Unknown BA9, Vermis
UMB-4898 Control M 7 12 Caucasian Methylphenidate; clonidine Drowning No No Unknown Vermis
UMB-1674 Control M 8 36 Caucasian None Drowning No No Unknown BA9, Vermis
UMB-4787 Control M 12 15 African American Montelukast; albuteral; prednisone, loratadine Asthma No No Unknown BA9, Vermis
UMB-1823 Control M 15 18 Caucasian None MVA No No Unknown BA9, Vermis
AN17425 Control M 16 26.16 Unknown None Heart attack No No Left BA9
AN15105 Control M 18 19.83 Unknown None Unknown No No Unknown BA9, Vermis
AN03217 Control M 19 18.58 Caucasian None Pneumonia No No Left BA9
UMB-1846 Control F 20 9 Caucasian None MVA No No Unknown BA9, Vermis
AN07176 Control M 21 29.91 Unknown None MVA No No Left BA9
AN14368 Control M 22 24.2 Unknown None Unknown No No Left BA9
AN19760 Control M 28 23.25 Unknown None Unknown No No Left BA9
AN15566 Control F 32 28.92 Unknown None Unknown No No Left BA9, Vermis
UMB-1169 Control M 33 27 African American Metoclopramide; loratadine Dilated cardiomyopathy (morbid obesity) No No Unknown BA9, Vermis
UMB-1376 Control M 37 12 African American None ASCVD No No Unknown BA9, Vermis
AN15151 Control M 41 30.4 Unknown None Heart attack No No Unknown BA9, Vermis
AN19440 Control F 50 20.25 Unknown None Heart attack No No Unknown BA9
AN12240 Control M 51 4.75 Caucasian None Heart attack No No Right BA9
AN13295 Control M 56 22.12 Unknown None Unknown No No Right BA9
AN08873 Autism M 5 25.5 Caucasian None Drowning No No Left BA9
AN13872 Autism F 5 32.73 Asian None Drowning No No Left BA9, Vermis
UMB-1349 Autism M 5 39 Caucasian None Drowning No No Unknown Vermis
UMB-1174 Autism F 7 14 Caucasian None Seizure disorder Yes No Unknown BA9
UMB-4231 Autism M 8 12 African American Olanzapine; galantamine Drowning No Yes Unknown BA9, Vermis
AN19511 Autism M 8 22.16 Caucasian None Cancer Yes No Left BA9, Vermis
UMB-4721 Autism M 8 16 African American None Drowning No No Unknown Vermis
AN16641 Autism M 9 27 Caucasian Carbamazepine; methylphenidate; clonidine Seizure disorder Yes Yes Left BA9
AN16115 Autism F 11 12.88 Caucasian Carbamazepine; lamotrigine; dextroamphetamine; topiramate Seizure/drowning Yes Yes Right Vermis
UMB-4899 Autism M 14 9 Caucasian None Drowning No No Unknown BA9, Vermis
AN17138 Autism M 16 24 Asian Fexofenadine; buspirone; topiramate Seizure disorder Yes No Left BA9, Vermis
AN01570 Autism F 18 6.75 Caucasian None Seizure disorder Yes No Right BA9
AN00764 Autism M 20 23.66 Caucasian Erythromycin gel; minocycline MVA No Yes Left BA9
UMB-1638 Autism F 20 50 Caucasian None Seizure disorder Yes Yes Unknown BA9
AN09730 Autism M 22 25 Caucasian Aripiprazole; lamotrigine; zonisamide Aspiration Yes No Left BA9, Vermis
AN08166 Autism M 29 43.25 Caucasian Fexofenadine; ziprasidone HCl; carbamazepine Seizure (suspected) Yes No Left BA9, Vermis
AN12457 Autism F 29 17.83 Caucasian Fluvoxamine Seizure disorder Yes No Left BA9, Vermis
AN11989 Autism M 30 16.06 Caucasian None Heart failure (congestive) No No Left BA9
AN08792 Autism M 30 20.33 Caucasian Cisapride; clorazepate; sodium valproate; phenytoin; folic acid; primidone; phenobarbital; omeprazole; metoclopramide Gastrointestinal bleeding Yes No Left BA9, Vermis
UMB-5027 Autism M 37 26 African American None Obstruction of bowel due to adhesion No No Unknown BA9, Vermis
AN06420 Autism M 39 13.95 Caucasian None Cardiac tamponade No No Left BA9, Vermis
AN14613 Autism M 39 22.75 Caucasian None Sudden unexpected death Yes No Unknown BA9
AN17777 Autism F 49 16.33 Caucasian Wafarin; venlafaxine; erythromycin; lansoprazole; risperidone; metformin; gabapentin; propranolol; levothyroxine Pulmonary arrest No Yes Left BA9, Vermis
AN01093 Autism M 56 19.48 Caucasian Benztropine mesylate; haloperidol; lithium; chlorpromazine; alprazolam Anoxic encephalopathy Yes No Right BA9, Vermis
Children Control Autistic Change P -value d  
Age ± SD (years) 11.4 ± 5.22 9.5 ± 4.38 ↓16.6% ns nd  
PMI ± SD (years) 20.6 ± 8.1 20.1 ± 9.94 ↓2.4% ns nd  
Gender 7M 8M:4F nd nd nd  
Adults Control Autistic Change P- value d  
Age ± SD (years) 34.2 ± 13 33.3 ± 11.2 ↓2.6% ns nd  
PMI ± SD (years) 20.9 ± 8.41 24.6 ± 11.1 ↑17.7% ns nd  
Gender 9M:3F 9M:3F nd nd nd  
  1. ASCVD, Arteriosclerotic cardiovascular disease; Dx, Diagnosis; Hrs, Hours; PMI, Postmortem interval; M, Male; F, Female; EtOH, Alcohol; ID, Intellectual disability; MVA, Motor vehicle accident; nd, Not determined; ns, Not significant; d, Cohen’s test statistic.