Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism

Table 1 Percentage of TD and AU children and their parents with mtDNA deletions

Mitochondrial gene	Individuals with mtDNA deletions
	Children			Mothers			Fathers
	TD	AU	P-value	TD	AU	P-value	TD	AU	P-value
Number	46	67		37	49		37	49
CYTB deletions, %	8.7	20.9	< 0.001	10.8	6.1	0.02	10.8	14.6*	0.030
ND4 deletions, %	6.5	14.9	< 0.001	8.1	4.1	0.02	5.4	10.2**	0.009
CYTB/ND4 fold change, %	1.3	1.4		1.3	1.5		2.0	1.4

Individuals with a Z-score < −2SD were considered as having deletions. The mean and SD utilized for the Z-scores were obtained from TD values from each of the groups (child, mother, father). The significance shown in the Table is for each AU vs. TD comparison. *P = 0.017 and **P = 0.030 vs. mothers of AU children. mtDNA mitochondrial DNA; TD typically developing; AU full autism.

ISSN: 2040-2392