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Table 1 Clinical characteristics of control individuals and subjects with high-functioning ASD

From: Serum levels of soluble platelet endothelial cell adhesion molecule-1 and vascular cell adhesion molecule-1 are decreased in subjects with autism spectrum disorder

Group Control (number = 29) ASD (number = 22) P-value
Age, years 11.6 ± 1.9 (8 to 16) 11.5 ± 3.2 (5 to 17) NS
Weight, kg 40 ± 9.9 (24 to 57.6) 41.4 ± 16.5 (17.5 to 96.6) NS
Height, cm 149.3 ± 11.9 (121.4 to 167) 147 ± 18.3 (110 to 178) NS
BMI, kg/m2 17.7 ± 2.3 (14.4 to 25.3) 18.5 ± 3.5 (13.9 to 30.5) NS
CRP, mg/dl 0.02 ± 0.02 (0.01 to 0.08) 0.13 ± 0.44 (0.01 to 2.30) NS
ADI-R
Domain A score N/A 20.7 ± 5.0 (10 to 27)  
Domain BV score N/A 14.2 ± 4.2 (8 to 21)  
Domain C score N/A 5.3 ± 2.0 (3 to 9)  
Domain D score N/A 3.2 ± 1.0 (2 to 5)  
Sum N/A 43.5 ± 9.6 (28– to 0)  
WISC-III    
Full-scale IQ 103.5 ± 13.1 (82 to 129) 97.2 ± 17.7 (72 to 134) NS
Adhesion molecules    
sPECAM-1 (ng/ml) 77.8 ± 13.2 (41.9 to 99.3) 58.4 ± 12.5 (36.4 to 82.4) <0.0001
sE-Selectin (micro g/ml) 44.8 ± 13.2 (24.1 to 89.7) 42.9 ± 19.1 (13.1 to 93.2) NS
sP-Selectin (micro g/ml) 69.5 ± 21.2 (38.9 to 125.5) 78.1 ± 28.9 (39 to 137.5) NS
sICAM-1 (micro g/ml) 325.8 ± 41.5 (243.8 to 422.1) 323.3 ± 56.4 (223.5 to 428.2) NS
sVCAM-1 (micro g/ml) 916.5 ± 106.6 (749.4 to 1160.8) 810.5 ± 146.8 (561.8 to 1162.5) 0.0042
  1. Values are expressed as mean ± s.d. (range). ADI-R Autism Diagnostic Interview-Revised, ASD autism spectrum disorder, BMI body mass index, CRP C-reactive protein, ICAM-1 intracellular adhesion molecule-1, IQ intelligence quotient, N/A not applicable, NS not significant, PECAM-1 platelet-endothelial adhesion molecule-1, s soluble, VCAM-1 vascular cell adhesion molecule-1, WISC-III Wechsler Intelligence Scale for Children, Third Edition.