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Table 5 Medical comorbidities identified from clinical interviews and medical record reviews (n = 32)

From: Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency

Medical comorbidity

N

%

Estimated frequency from previous reports[50]

Increased pain tolerance

28

88

>50%

Hypotonia

24

75

>75%

Recurring upper respiratory tract infections

17

53

 

Gastroesophageal reflux

14

44

>25%

Sleep disturbance

13

41

 

Seizures (febrile and/or non-febrile)

13

41

>25%

Constipation and/or diarrhea

12

38

 

Renal abnormalities

12

38

>25%

Lymphedema

7

22

>25%

Seasonal allergies

6

19

 

Food allergies

5

16

 

Asthma

3

9

 

Strabismus

2

6

>25%

Cardiac abnormalities

1

3

>25%

Hypothyroidism

1

3

5%

Hypertrichosis

1

3

 

Vitiligo

1

3

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