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Table 5 Medical comorbidities identified from clinical interviews and medical record reviews (n = 32)

From: Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency

Medical comorbidity N % Estimated frequency from previous reports[50]
Increased pain tolerance 28 88 >50%
Hypotonia 24 75 >75%
Recurring upper respiratory tract infections 17 53  
Gastroesophageal reflux 14 44 >25%
Sleep disturbance 13 41  
Seizures (febrile and/or non-febrile) 13 41 >25%
Constipation and/or diarrhea 12 38  
Renal abnormalities 12 38 >25%
Lymphedema 7 22 >25%
Seasonal allergies 6 19  
Food allergies 5 16  
Asthma 3 9  
Strabismus 2 6 >25%
Cardiac abnormalities 1 3 >25%
Hypothyroidism 1 3 5%
Hypertrichosis 1 3  
Vitiligo 1 3