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Table 5 Enrichment data and genomic location of the RORA-binding enriched regions closest to the selected genes

From: Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder

Nearest gene

Entrez gene name

MAT score on T (R vs. G)

P value (region)

FDR (%)

Average intensity fold-change (R vs. G)

Chromosome (strand)

Region start

Length (bps)

Number of probes in region

ITPR1

Inositol 1,4,5-triphosphate receptor, type 1

17.19

0.005

<5

1.29

chr3 (+)

4,724,792

2,804

71

HSD17B10

Hydroxysteroid (17-β) dehydrogenase 10

14.11

0.007

<5

11.86

chrX (−)

53,483,92

1,723

42

A2BP1 (RBFOX1)

RNA binding protein, fox-1 homolog

12.86

0.009

<5

1.29

chr16 (+)

7,315,418

2,636

68

NLGN1

Neuroligin 1

7.30

0.036

<5

3.27

chr3 (+)

174,777,672

639

18

CYP19A1 (aromatase)

Cytochrome P450, family 19, subfamily A, polypeptide 1

7.02

0.040

<5

1.61

chr15 (−)

49,415,636

2,111

54

NTRK2

Neurotrophic tyrosine kinase, receptor, type 2

6.72

0.044

<7

2.17

chr9 (+)

86,412,498

966

21

  1. FDR false discovery rate, G intensity of probes hybridized with DNA fragments immunoprecipitated with nonspecific IgG, MAT model-based analysis of tiling arrays, R intensity of probes hybridized with DNA fragments immunoprecipitated with anti-RORA antibody, T t-statistic.