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Table 5 Enrichment data and genomic location of the RORA-binding enriched regions closest to the selected genes

From: Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder

Nearest gene Entrez gene name MAT score on T (R vs. G) P value (region) FDR (%) Average intensity fold-change (R vs. G) Chromosome (strand) Region start Length (bps) Number of probes in region
ITPR1 Inositol 1,4,5-triphosphate receptor, type 1 17.19 0.005 <5 1.29 chr3 (+) 4,724,792 2,804 71
HSD17B10 Hydroxysteroid (17-β) dehydrogenase 10 14.11 0.007 <5 11.86 chrX (−) 53,483,92 1,723 42
A2BP1 (RBFOX1) RNA binding protein, fox-1 homolog 12.86 0.009 <5 1.29 chr16 (+) 7,315,418 2,636 68
NLGN1 Neuroligin 1 7.30 0.036 <5 3.27 chr3 (+) 174,777,672 639 18
CYP19A1 (aromatase) Cytochrome P450, family 19, subfamily A, polypeptide 1 7.02 0.040 <5 1.61 chr15 (−) 49,415,636 2,111 54
NTRK2 Neurotrophic tyrosine kinase, receptor, type 2 6.72 0.044 <7 2.17 chr9 (+) 86,412,498 966 21
  1. FDR false discovery rate, G intensity of probes hybridized with DNA fragments immunoprecipitated with nonspecific IgG, MAT model-based analysis of tiling arrays, R intensity of probes hybridized with DNA fragments immunoprecipitated with anti-RORA antibody, T t-statistic.