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Table 3 Top neurological diseases, disorders, and behaviors associated with the 2,544 potential transcriptional targets of RORA

From: Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder

Function annotation (number of molecules) P value
Nervous system development and function  
Quantity of neurons (67) 5.83E-08
Development of brain (102) 9.01E-08
Morphology of nervous system (161) 3.96E-07
Morphology of nervous tissue (118) 5.44E-07
Development of central nervous system (122) 1.50E-06
Axonogenesis (43) 1.68E-05
Morphology of nerves (30) 7.32E-05
Cell-cell adhesion of neurons (6) 1.48E-04
Morphology of central nervous system (98) 1.90E-04
Morphology of rhombencephalon (35) 2.41E-04
Quantity of sensory neurons (19) 2.81E-04
Development of nerves (19) 2.81E-04
Abnormal morphology of neurons (51) 2.85E-04
Morphology of neurons (55) 3.37E-04
Antinociception (13) 3.84E-04
Development of neurons (37) 3.98E-04
Morphology of brain (88) 4.40E-04
Development of interneurons (7) 4.56E-04
Migration of neurons (46) 4.79E-04
Abnormal morphology of cerebellum (21) 5.58E-04
Development of metencephalon (24) 5.88E-04
Loss of neurons (29) 8.01E-04
Long-term potentiation of granule cells (4) 8.18E-04
Abnormal morphology of cranial nerve (19) 8.60E-04
Neuritogenesis (83) 1.11E-03
Development of cerebellum (23) 1.22E-03
Development of forebrain (45) 1.26E-03
Fasciculation of nervous tissue (9) 1.34E-03
Abnormal morphology of granule cells (12) 1.42E-03
Development of globus pallidus (3) 1.56E-03
Activation of hippocampus (3) 1.56E-03
Abnormal morphology of hair cells (9) 1.84E-03
Morphogenesis of neurites (58) 1.85E-03
Adhesion of neuronal cells (14) 1.88E-03
Abnormal morphology of outer hair cells (6) 2.01E-03
Sensory system development (23) 2.09E-03
Development of rhombencephalon (28) 2.15E-03
Chemotaxis of granule cells (4) 2.23E-03
Guidance of axons (31) 2.24E-03
Morphology of mechanosensory neurons (10) 2.49E-03
Cell viability of neurons (39) 2.51E-03
Analgesia (18) 2.62E-03
Synaptic transmission of cerebral cortex cells (11) 3.03E-03
Memory (39) 3.52E-03
Neurotransmission (71) 3.75E-03
Development of cranial nerve (11) 3.79E-03
Cell viability of granule cells (8) 4.28E-03
Neurological disease  
Schizophrenia (107) 8.09E-06
Chorea (117) 3.23E-04
Huntington's Disease (116) 4.09E-04
Movement Disorders (183) 9.11E-04
Dyskinesia (118) 1.27E-03
Neurological signs (120) 1.45E-03
Familial transthyretin amyloidosis (3) 1.56E-03
Seizure disorder (60) 3.92E-03
Disorder of basal ganglia (135) 4.31E-03
Polymicrogyria (4) 4.72E-03
Behavior (180) 2.74E-07
Cognition (79) 1.70E-05
Learning (74) 3.41E-05
Circling behavior (12) 1.11E-03
Emotional behavior (42) 3.04E-03
Memory (39) 3.52E-03
Spatial learning (33) 4.23E-03
  1. These data were obtained using Ingenuity Pathway Analysis software. P values were calculated using Fisher's exact test, which was performed using the entire set of genes within the Ingenuity Knowledge Base as the reference set.