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Table 3 Top neurological diseases, disorders, and behaviors associated with the 2,544 potential transcriptional targets of RORA

From: Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder

Function annotation (number of molecules)

P value

Nervous system development and function

 

Quantity of neurons (67)

5.83E-08

Development of brain (102)

9.01E-08

Morphology of nervous system (161)

3.96E-07

Morphology of nervous tissue (118)

5.44E-07

Development of central nervous system (122)

1.50E-06

Axonogenesis (43)

1.68E-05

Morphology of nerves (30)

7.32E-05

Cell-cell adhesion of neurons (6)

1.48E-04

Morphology of central nervous system (98)

1.90E-04

Morphology of rhombencephalon (35)

2.41E-04

Quantity of sensory neurons (19)

2.81E-04

Development of nerves (19)

2.81E-04

Abnormal morphology of neurons (51)

2.85E-04

Morphology of neurons (55)

3.37E-04

Antinociception (13)

3.84E-04

Development of neurons (37)

3.98E-04

Morphology of brain (88)

4.40E-04

Development of interneurons (7)

4.56E-04

Migration of neurons (46)

4.79E-04

Abnormal morphology of cerebellum (21)

5.58E-04

Development of metencephalon (24)

5.88E-04

Loss of neurons (29)

8.01E-04

Long-term potentiation of granule cells (4)

8.18E-04

Abnormal morphology of cranial nerve (19)

8.60E-04

Neuritogenesis (83)

1.11E-03

Development of cerebellum (23)

1.22E-03

Development of forebrain (45)

1.26E-03

Fasciculation of nervous tissue (9)

1.34E-03

Abnormal morphology of granule cells (12)

1.42E-03

Development of globus pallidus (3)

1.56E-03

Activation of hippocampus (3)

1.56E-03

Abnormal morphology of hair cells (9)

1.84E-03

Morphogenesis of neurites (58)

1.85E-03

Adhesion of neuronal cells (14)

1.88E-03

Abnormal morphology of outer hair cells (6)

2.01E-03

Sensory system development (23)

2.09E-03

Development of rhombencephalon (28)

2.15E-03

Chemotaxis of granule cells (4)

2.23E-03

Guidance of axons (31)

2.24E-03

Morphology of mechanosensory neurons (10)

2.49E-03

Cell viability of neurons (39)

2.51E-03

Analgesia (18)

2.62E-03

Synaptic transmission of cerebral cortex cells (11)

3.03E-03

Memory (39)

3.52E-03

Neurotransmission (71)

3.75E-03

Development of cranial nerve (11)

3.79E-03

Cell viability of granule cells (8)

4.28E-03

Neurological disease

 

Schizophrenia (107)

8.09E-06

Chorea (117)

3.23E-04

Huntington's Disease (116)

4.09E-04

Movement Disorders (183)

9.11E-04

Dyskinesia (118)

1.27E-03

Neurological signs (120)

1.45E-03

Familial transthyretin amyloidosis (3)

1.56E-03

Seizure disorder (60)

3.92E-03

Disorder of basal ganglia (135)

4.31E-03

Polymicrogyria (4)

4.72E-03

Behavior

 

Behavior (180)

2.74E-07

Cognition (79)

1.70E-05

Learning (74)

3.41E-05

Circling behavior (12)

1.11E-03

Emotional behavior (42)

3.04E-03

Memory (39)

3.52E-03

Spatial learning (33)

4.23E-03

  1. These data were obtained using Ingenuity Pathway Analysis software. P values were calculated using Fisher's exact test, which was performed using the entire set of genes within the Ingenuity Knowledge Base as the reference set.