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Table 1 Top annotation cluster from gene ontology analysis of 2,544 potential transcriptional targets of RORA

From: Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder

Annotation cluster 1: enrichment score 5.107  
GO term Count P Value Benjamini* Genes
GO:0030182-neuron differentiation 35 1.52E-08 3.56E-05 RAB3A, CDK5R1, ADORA2A, PAX3, RORA, RTN1, EPHB2, ARX, ATP2B2, BDNF, SLC1A3, LAMB2, CD44, CXCR4, ANK3, DMD, ROBO3, LHX8, LMX1B, MDGA2, PTPRR, NTNG1, RPGRIP1, NUMBL, SOD2, PTPN11, CTNNA2, SLITRK1, NTRK1, NTRK2, FOXG1, CNTN4, CACNA1F, CUX1, NTM
GO:0048666-neuron development 28 2.96E-07 3.48E-04 RAB3A, CDK5R1, ADORA2A, EPHB2, ARX, ATP2B2, BDNF, SLC1A3, LAMB2, CD44, ANK3, CXCR4, DMD, ROBO3, LHX8, LMX1B, NTNG1, RPGRIP1, CTNNA2, PTPN11, SOD2, NUMBL, SLITRK1, FOXG1, NTRK2, CNTN4, CACNA1F, NTM
GO:0000904-cell morphogenesis involved in differentiation 22 1.86E-06 1.45E-03 RAB3A, CDK5R1, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, ATP2B2, DAB2, BDNF, SLC1A3, LAMB2, CXCR4, ANK3, LAMA5, FOXG1, CNTN4, ROBO3, CACNA1F, FN1
GO:0000902-cell morphogenesis 27 2.53E-06 1.48E-03 RAB3A, CDK5R1, ADORA2A, EPHB2, ARX, ATP2B2, BDNF, DAB2, SLC1A3, LAMB2, ANK3, CXCR4, DMD, MKKS, ROBO3, FN1, NTNG1, MARK2, CTNNA2, PTPN11, NUMBL, SLITRK1, LAMA5, FOXG1, CNTN4, CACNA1F, CDC42BPB
GO:0032989-cellular component morphogenesis 28 6.15E-06 2.88E-03 RAB3A, CDK5R1, ADORA2A, EPHB2, ARX, ATP2B2, DAB2, BDNF, SLC1A3, LAMB2, ANK3, CXCR4, DMD, OBSL1, MKKS, ROBO3, FN1, NTNG1, MARK2, CTNNA2, PTPN11, NUMBL, SLITRK1, LAMA5, FOXG1, CNTN4, CACNA1F, CDC42BPB
GO:0048858-cell projection morphogenesis 21 7.30E-06 2.14E-03 RAB3A, CDK5R1, ADORA2A, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, BDNF, LAMB2, CXCR4, ANK3, LAMA5, DMD, FOXG1, MKKS, CNTN4, ROBO3, CACNA1F
GO:0048667-cell morphogenesis involved in neuron differentiation 19 1.01E-05 2.63E-03 RAB3A, CDK5R1, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, ATP2B2, BDNF, SLC1A3, LAMB2, CXCR4, ANK3, FOXG1, CNTN4, ROBO3, CACNA1F
GO:0048812-neuron projection morphogenesis 19 1.31E-05 3.07E-03 RAB3A, CDK5R1, ADORA2A, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, BDNF, LAMB2, CXCR4, ANK3, DMD, FOXG1, CNTN4, ROBO3, CACNA1F
GO:0030030-cell projection organization 26 1.39E-05 2.96E-03 MTSS1, RAB3A, CDK5R1, DNAH9, ADORA2A, EPHB2, ARX, ATP2B2, BDNF, LAMB2, CD44, ANK3, CXCR4, DMD, MKKS, ROBO3, FGD3, NTNG1, CTNNA2, PTPN11, NUMBL, SLITRK1, LAMA5, FOXG1, CNTN4, CACNA1F
GO:0032990-cell part morphogenesis 21 1.40E-05 2.73E-03 RAB3A, CDK5R1, ADORA2A, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, BDNF, LAMB2, CXCR4, ANK3, LAMA5, DMD, FOXG1, MKKS, CNTN4, ROBO3, CACNA1F
GO:0031175-neuron projection development 20 4.65E-05 6.80E-03 RAB3A, CDK5R1, ADORA2A, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, BDNF, LAMB2, CD44, CXCR4, ANK3, DMD, FOXG1, CNTN4, ROBO3, CACNA1F
GO:0007409-axonogenesis 17 4.98E-05 6.86E-03 RAB3A, CDK5R1, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, BDNF, LAMB2, CXCR4, ANK3, FOXG1, CNTN4, ROBO3, CACNA1F
GO:0007411-axon guidance 9 7.12E-03 2.67E-01 ARX, CDK5R1, BDNF, CXCR4, ANK3, FOXG1, CNTN4, ROBO3, EPHB2
  1. Results were obtained using DAVID Bioinformatics Resources 6.7. The enrichment score is the negative logarithm of the average of P values for items within each cluster. *P values corrected for multiple testing.