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Table 1 Top annotation cluster from gene ontology analysis of 2,544 potential transcriptional targets of RORA

From: Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder

Annotation cluster 1: enrichment score 5.107

 

GO term

Count

P Value

Benjamini*

Genes

GO:0030182-neuron differentiation

35

1.52E-08

3.56E-05

RAB3A, CDK5R1, ADORA2A, PAX3, RORA, RTN1, EPHB2, ARX, ATP2B2, BDNF, SLC1A3, LAMB2, CD44, CXCR4, ANK3, DMD, ROBO3, LHX8, LMX1B, MDGA2, PTPRR, NTNG1, RPGRIP1, NUMBL, SOD2, PTPN11, CTNNA2, SLITRK1, NTRK1, NTRK2, FOXG1, CNTN4, CACNA1F, CUX1, NTM

GO:0048666-neuron development

28

2.96E-07

3.48E-04

RAB3A, CDK5R1, ADORA2A, EPHB2, ARX, ATP2B2, BDNF, SLC1A3, LAMB2, CD44, ANK3, CXCR4, DMD, ROBO3, LHX8, LMX1B, NTNG1, RPGRIP1, CTNNA2, PTPN11, SOD2, NUMBL, SLITRK1, FOXG1, NTRK2, CNTN4, CACNA1F, NTM

GO:0000904-cell morphogenesis involved in differentiation

22

1.86E-06

1.45E-03

RAB3A, CDK5R1, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, ATP2B2, DAB2, BDNF, SLC1A3, LAMB2, CXCR4, ANK3, LAMA5, FOXG1, CNTN4, ROBO3, CACNA1F, FN1

GO:0000902-cell morphogenesis

27

2.53E-06

1.48E-03

RAB3A, CDK5R1, ADORA2A, EPHB2, ARX, ATP2B2, BDNF, DAB2, SLC1A3, LAMB2, ANK3, CXCR4, DMD, MKKS, ROBO3, FN1, NTNG1, MARK2, CTNNA2, PTPN11, NUMBL, SLITRK1, LAMA5, FOXG1, CNTN4, CACNA1F, CDC42BPB

GO:0032989-cellular component morphogenesis

28

6.15E-06

2.88E-03

RAB3A, CDK5R1, ADORA2A, EPHB2, ARX, ATP2B2, DAB2, BDNF, SLC1A3, LAMB2, ANK3, CXCR4, DMD, OBSL1, MKKS, ROBO3, FN1, NTNG1, MARK2, CTNNA2, PTPN11, NUMBL, SLITRK1, LAMA5, FOXG1, CNTN4, CACNA1F, CDC42BPB

GO:0048858-cell projection morphogenesis

21

7.30E-06

2.14E-03

RAB3A, CDK5R1, ADORA2A, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, BDNF, LAMB2, CXCR4, ANK3, LAMA5, DMD, FOXG1, MKKS, CNTN4, ROBO3, CACNA1F

GO:0048667-cell morphogenesis involved in neuron differentiation

19

1.01E-05

2.63E-03

RAB3A, CDK5R1, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, ATP2B2, BDNF, SLC1A3, LAMB2, CXCR4, ANK3, FOXG1, CNTN4, ROBO3, CACNA1F

GO:0048812-neuron projection morphogenesis

19

1.31E-05

3.07E-03

RAB3A, CDK5R1, ADORA2A, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, BDNF, LAMB2, CXCR4, ANK3, DMD, FOXG1, CNTN4, ROBO3, CACNA1F

GO:0030030-cell projection organization

26

1.39E-05

2.96E-03

MTSS1, RAB3A, CDK5R1, DNAH9, ADORA2A, EPHB2, ARX, ATP2B2, BDNF, LAMB2, CD44, ANK3, CXCR4, DMD, MKKS, ROBO3, FGD3, NTNG1, CTNNA2, PTPN11, NUMBL, SLITRK1, LAMA5, FOXG1, CNTN4, CACNA1F

GO:0032990-cell part morphogenesis

21

1.40E-05

2.73E-03

RAB3A, CDK5R1, ADORA2A, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, BDNF, LAMB2, CXCR4, ANK3, LAMA5, DMD, FOXG1, MKKS, CNTN4, ROBO3, CACNA1F

GO:0031175-neuron projection development

20

4.65E-05

6.80E-03

RAB3A, CDK5R1, ADORA2A, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, BDNF, LAMB2, CD44, CXCR4, ANK3, DMD, FOXG1, CNTN4, ROBO3, CACNA1F

GO:0007409-axonogenesis

17

4.98E-05

6.86E-03

RAB3A, CDK5R1, NTNG1, PTPN11, CTNNA2, EPHB2, NUMBL, ARX, SLITRK1, BDNF, LAMB2, CXCR4, ANK3, FOXG1, CNTN4, ROBO3, CACNA1F

GO:0007411-axon guidance

9

7.12E-03

2.67E-01

ARX, CDK5R1, BDNF, CXCR4, ANK3, FOXG1, CNTN4, ROBO3, EPHB2

  1. Results were obtained using DAVID Bioinformatics Resources 6.7. The enrichment score is the negative logarithm of the average of P values for items within each cluster. *P values corrected for multiple testing.
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Molecular Autism

ISSN: 2040-2392