Figure 1

Summary of single nucleotide variants (SNV) and insertions or deletions (indel) variation discovered at the NLGN3 and NLGN4X loci in male individuals with autism spectrum disorder (ASD). The frequency of SNVs and indels (minor alleles) in cases is plotted against their level of evolutionary conservation. Most common variation has already been discovered and exists in public databases (blue; circles and diamonds). Most of the rare variation at both loci was discovered in our study and not contained in public databases (red; circles and diamonds).