Figure 1

Regional plots of immune ASD loci. Genotyped (circles) and imputed (triangles) SNPs are plotted with their P-values (as -log₁₀ values) as a function of genomic position (Human Genome Build 18) within a region surrounding the most significant SNP (purple color). Recombination rates from the HapMap Phase II CEU are plotted in blue to reflect the regional LD structure. In each region, the index SNP is represented by a large purple symbol, and the color of all other SNPs indicates LD with the index SNP based on pairwise r² values from HapMap CEU (red, r² > 0.8; orange, r² = 0.6 to 0.8; green, r² = 0.4 to 0.6; light blue, r² = 0.2 to 0.4; dark blue, r² < 0.2). Known human genes in the UCSC Genome Browser are in the bottom.