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Table 1 10 α 1 subunit calcium channel genes tested for association with ASD

From: Support for calcium channel gene defects in autism spectrum disorders

Gene symbol (Chrom band) Channel Current typea Most dominant brain expressed regiona Cells and tissues with gene expression in addition to brain
Ca v 1 subfamily
CACNA1S (1q32) Cav1.1 L MD Skeletal muscle; transverse tubules
CACNA1C (12p13.3) Cav1.2 L MD Cardiac myocytes; smooth muscle myocytes; endocrine cells; neurons
CACNA1D (3p14.3) Cav1.3 L NCX Endocrine cells; neurons; cardiac cells and pacemaker cells; cochlear hair cells
CACNA1F (Xp11.23) CaV1.4 L Amygdala Retina; spinal cord; adrenal gland; mast cells
Ca v 2 subfamily
CACNA1A (19p13) Cav2.1 P/Q CBC Neurons
CACNA1B (9q34) Cav2.2 N MD Neurons
CACNA1E (1q25-q31) Cav2.3 R Striatum Neurons
Ca v 3 subfamily
CACNA1G (17q21) Cav3.1 T MD Neurons; smooth muscle myocytes
CACNA1H (16p13.3) Cav3.2 T Striatum Neurons; cardiac and smooth muscle myocytes
CACNA1I (22q13.1) Cav3.3 T NCX Neurons
  1. aCurrent types were defined based on different properties in biophysical and pharmacological analysis.
  2. CBC Cerebellar cortex; L Long lasting; MD Mediodorsal nucleus of the thalamus; N Neither long nor transient lasting; NCX, Areas of neocortex; P, Cerebellar Purkinje cell; Q Indicating different toxic sensitivity and inactivation rate from the P-type in α1A subunit [11]; R Resistent; T Transient lasting.