Failure to deactivate the default mode network indicates a possible endophenotype of autism

Table 2 Between-group differences in deactivation (that is, CT>EFT) – all analyses take age and sex as covariates

Region of commonality of significant deactivation in all three groups	Between-group differences			Effect of group (across all three groups)	Polynomial regression linear trend effect
	P-value (F statistic)			Effect of group (across all three groups)	Polynomial regression linear trend effect
	Control versus sibling	Control versus autism	Sibling versus autism	P-value (F statistic)	P-value
CT versus EFT
RIPC	0.020 (5.675)	0.051 (3.952)	NS	0.040 (3.313)	0.043
PCC	0.064 (3.528)	0.057 (3.755)	NS	0.070 (2.724)	0.054
LIPC	0.061 (3.625)	NS	NS	NS	NS
LSTS	NS	NS	NS	NS	NS
LAPFC	NS	NS	NS	NS	NS
RSTS	NS	NS	NS	NS	NS

CT, control task; EFT, Embedded Figures Task; LAPFC, left anterior prefrontal cortex; LIPC, left inferior parietal cortex; LSTS, left superior temporal sulcus; NS, not significant; PCC, posterior cingulate cortex; RIPC, right inferior parietal cortex; RSTS, right superior temporal sulcus.

ISSN: 2040-2392