Neuroanatomical characterization of Vldlr transgenic (Tg) rats. (A) Histology of the hippocampus and cerebellum in adult (2 to 3 months) wild-type (Wt) and transgenic (Tg) rats. Panels show Nissl-stained coronal sections of the hippocampus or sagittal sections of the cerebellum. The results are representative of three independent experiments. Scale bars, 1 mm. (B) Cortical layering in adult (2 to 3 months) Wt and Tg rats. Panels show immunohistochemical NeuN staining. Cortical layers are numbered I to VI. The results are representative of three independent experiments (Additional file 3: Supplementary method). Scale bar, 100 μm.