Schematic representation of the canonical Wnt2 pathway, including all genes discussed in the current review. Wnt2 activates the 7-transmembrane-spanning Fzd9 receptor, which together with the co-receptor LRP5/6 activates dishevelled (DVL). Activated DVL inhibits the activity of the β-catenin “destruction complex” (indicated as a light blue ellipse). β-catenin is released from its complex with cadherin by the activity of the HGF receptor MET. When β-catenin is protected against destruction, it can enter the nucleus, bind the transcription factor LEF1 and co-factors to promote transcription of target genes like, for example, engrailed 2 (EN2). The functional consequence is an increase in cell growth and motility.