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Figure 1 | Molecular Autism

Figure 1

From: Optimizing the phenotyping of rodent ASD models: enrichment analysis of mouse and human neurobiological phenotypes associated with high-risk autism genes identifies morphological, electrophysiological, neurological, and behavioral features

Figure 1

Mouse phenotype categories associated with ASD genes. ASD genes (n = 112) were analyzed for enrichment in mouse phenotypes using ToppGene with a Bonferroni corrected P value cutoff of 0.01. Categories are arranged from most significant and downwards (purple line), and for each category, the number of genes in the ASD112 list for which there were murine models with the associated category are indicted by the length of the horizontal bars (gene count). To highlight differing phenotypic categories discussed in the text, bars are color-coded as indicated in the inset to the figure. Categories relating to nervous system morphology phenotype domains are colored light blue, while other morphological categories are colored dark blue, electrophysiological categories are colored pink, neurological categories are colored peach, and higher-order behavioral categories are colored green. Categories corresponding to more than one phenotyping domain are presented as alternating colors, and categories that do not relate to our phenotyping scheme are colored yellow. All data are also found in tabular form in Additional file 2.

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Molecular Autism

ISSN: 2040-2392