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Table 9 Four ADI-R Trait scores highlighted by Silverman [20], grouped by the presence or absence of at least one A allele for rs2056202 and rs2292813.a,b

From: A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disorders

 

Age at phrase speechc, months

Level of language

Circumscribed interests

Routines and rituals

UIC sample (n = 88 probands)

   

rs2056202

    

1+A allele (n = 50)

40.0 ± 3.3

0.28 ± 0.09

1.80 ± 0.23

1.44 ± 0.25

G/G (n = 120)

40.5 ± 2.4

0.21 ± 0.07

1.72 ± 0.18

1.81 ± 0.20

Statistics

F(1,70) = 0.02, p = 0.903

F(1,86) = 0.38, p = 0.542

F(1,86) = 0.08, p = 0.783

F(1,86) = 1.36, p = 0.248

rs2292813

    

1+A allele (n = 50)

39.2 ± 3.7

0.27 ± 0.11

1.72 ± 0.26

1.44 ± 0.29

G/G (n = 120)

40.8 ± 2.3

0.23 ± 0.07

1.76 ± 0.16

1.76 ± 0.18

Statistics

F(1,70) = 0.17, p = 0.679

F(1,86) = 0.10, p = 0.753

F(1,86) = 0.02, P = 0.883

F(1,86) = 0.91, p = 0.344

SSC sample (n = 720 probands)

   

rs2056202

    

1+A allele (n = 50)

37.5 ± 1.4

0.03 ± 0.02

1.84 ± 0.08

1.68 ± 0.10

G/G (n = 120)

38.3 ± 0.9

0.10 ± 0.01

1.87 ± 0.05

1.63 ± 0.06

Statistics

F(1,668) = 0.29, p = 0.590

F(1,718) = 6.71, p = 0.010e

F(1,718) = 0.12, p = 0.735

F(1,718) = 0.15, p = 0.701

rs2292813

    

1+A allele (n = 50)

38.0 ± 1.7

0.03 ± 0.03

1.71 ± 0.10

1.67 ± 0.12

G/G (n = 120)

38.1 ± 0.8

0.09 ± 0.01

1.90 ± 0.05

1.64 ± 0.06

Statistics

F(1,668) = 0.01, p = 0.943

F(1,718) = 4.42, p = 0.036e

F(1,718) = 2.97, p = 0.085f

F(1,718) = 0.06, p = 0.812

Silverman studyd (n = 170 probands)

   

rs2056202

    

1+A allele (n = 50)

45 ± 2

0.90 ± 0.12

1.31 ± 0.11

0.79 ± 0.17

G/G (n = 120)

44 ± 4

0.63 ± 0.08

1.54 ± 1.21

1.30 ± 0.11

Statistics

F(1,166) = 0.05, p = 0.83

F(1,166) = 3.25, p = 0.07f

F(1,166) = 1.36, p = 0.25

F(1,166) = 6.49, p = 0.0117e

  1. aGender and age were used as covariates and estimated marginal means ± standard errorsE are reported.
  2. bAll p values are uncorrected for multiple comparisons.
  3. c993-999 codes were treated as missing for Age at phrase speech.
  4. dSilverman (2008) study data are shown for comparison.
  5. P value: ep< 0.05; fp< 0.1.