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Table 9 Four ADI-R Trait scores highlighted by Silverman [20], grouped by the presence or absence of at least one A allele for rs2056202 and rs2292813.a,b

From: A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disorders

  Age at phrase speechc, months Level of language Circumscribed interests Routines and rituals
UIC sample (n = 88 probands)    
rs2056202     
1+A allele (n = 50) 40.0 ± 3.3 0.28 ± 0.09 1.80 ± 0.23 1.44 ± 0.25
G/G (n = 120) 40.5 ± 2.4 0.21 ± 0.07 1.72 ± 0.18 1.81 ± 0.20
Statistics F(1,70) = 0.02, p = 0.903 F(1,86) = 0.38, p = 0.542 F(1,86) = 0.08, p = 0.783 F(1,86) = 1.36, p = 0.248
rs2292813     
1+A allele (n = 50) 39.2 ± 3.7 0.27 ± 0.11 1.72 ± 0.26 1.44 ± 0.29
G/G (n = 120) 40.8 ± 2.3 0.23 ± 0.07 1.76 ± 0.16 1.76 ± 0.18
Statistics F(1,70) = 0.17, p = 0.679 F(1,86) = 0.10, p = 0.753 F(1,86) = 0.02, P = 0.883 F(1,86) = 0.91, p = 0.344
SSC sample (n = 720 probands)    
rs2056202     
1+A allele (n = 50) 37.5 ± 1.4 0.03 ± 0.02 1.84 ± 0.08 1.68 ± 0.10
G/G (n = 120) 38.3 ± 0.9 0.10 ± 0.01 1.87 ± 0.05 1.63 ± 0.06
Statistics F(1,668) = 0.29, p = 0.590 F(1,718) = 6.71, p = 0.010e F(1,718) = 0.12, p = 0.735 F(1,718) = 0.15, p = 0.701
rs2292813     
1+A allele (n = 50) 38.0 ± 1.7 0.03 ± 0.03 1.71 ± 0.10 1.67 ± 0.12
G/G (n = 120) 38.1 ± 0.8 0.09 ± 0.01 1.90 ± 0.05 1.64 ± 0.06
Statistics F(1,668) = 0.01, p = 0.943 F(1,718) = 4.42, p = 0.036e F(1,718) = 2.97, p = 0.085f F(1,718) = 0.06, p = 0.812
Silverman studyd (n = 170 probands)    
rs2056202     
1+A allele (n = 50) 45 ± 2 0.90 ± 0.12 1.31 ± 0.11 0.79 ± 0.17
G/G (n = 120) 44 ± 4 0.63 ± 0.08 1.54 ± 1.21 1.30 ± 0.11
Statistics F(1,166) = 0.05, p = 0.83 F(1,166) = 3.25, p = 0.07f F(1,166) = 1.36, p = 0.25 F(1,166) = 6.49, p = 0.0117e
  1. aGender and age were used as covariates and estimated marginal means ± standard errorsE are reported.
  2. bAll p values are uncorrected for multiple comparisons.
  3. c993-999 codes were treated as missing for Age at phrase speech.
  4. dSilverman (2008) study data are shown for comparison.
  5. P value: ep< 0.05; fp< 0.1.