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Table 5 Haplotype analyses for association between quantitative RRB traits and rs2056202-rs2292813 haplotype

From: A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disorders

  UIC-UF sample (n = 179 probands) SSC sample (n = 720 probands)
Haplotype (frequency) A-A (0.163) A-G (0.056) G-G (0.781) Omnibus A-A (0.107) A-G (0.045) G-G (0.849) Omnibus
Stereotyped behavior         
βa 0.271 -0.062 -0.201 N/A 0.054 0.408 -0.186 N/A
Statb 3.400 0.078 2.250 3.380 0.394 11.700 6.650 12.500
EMP1c 0.062 0.787 0.134 0.184 0.531 0.000 0.009 0.002
Permutation p 0.146 0.955 0.285 0.184 0.802 0.002 d 0.022 d 0.002 d
Self-injurious behavior         
βa 0.285 -0.102 -0.196 N/A 0.010 0.431 -0.165 N/A
Statb 3.500 0.203 2.000 3.500 0.014 13.000 5.140 13.100
EMP1c 0.064 0.644 0.155 0.173 0.914 0.001 0.022 0.003
Permutation p 0.139 0.887 0.319 0.173 0.993 0.002 d 0.054 e 0.003 d
Compulsive behavior         
βa 0.132 -0.222 -0.024 N/A 0.005 0.324 -0.123 N/A
Statb 0.734 0.962 0.030 1.440 0.003 7.220 2.810 7.300
EMP1c 0.389 0.329 0.860 0.487 0.957 0.007 0.095 0.021
Permutation p 0.659 0.581 0.983 0.487 0.998 0.020 d 0.209 0.021 d
Ritualistic behavior         
βa 0.406 -0.096 -0.298 N/A 0.042 0.242 -0.119 N/A
Statb 7.340 0.181 4.720 7.300 0.237 4.080 2.680 4.500
EMP1c 0.007 0.666 0.032 0.028 0.626 0.043 0.104 0.110
Permutation p 0.020 d 0.903 0.078 e 0.028 d 0.878 0.104 0.222 0.110
Sameness behavior         
βa 0.420 -0.156 -0.284 N/A 0.155 0.223 -0.193 N/A
Statb 7.550 0.465 4.140 7.550 3.270 3.470 7.100 7.350
EMP1c 0.008 0.510 0.043 0.025 0.073 0.065 0.010 0.028
Permutation p 0.017 d 0.780 0.103 0.025 d 0.164 0.148 0.023 d 0.028 d
Restricted behavior         
βa 0.293 -0.383 -0.096 N/A 0.166 0.228 -0.202 N/A
Statb 3.840 3.000 0.493 5.840 3.790 3.680 7.930 8.160
EMP1c 0.049 0.088 0.482 0.054 0.053 0.056 0.006 0.019
Permutation p 0.118 0.194 0.759 0.054 e 0.121 0.128 0.014 d 0.019 d
Sum         
βa 0.392 -0.171 -0.260 N/A 0.084 0.349 -0.188 N/A
Statb 6.530 0.541 3.410 6.580 0.941 8.130 6.470 9.630
EMP1c 0.011 0.465 0.069 0.040 0.325 0.006 0.012 0.009
Permutation p 0.029 d 0.735 0.154 0.040 d 0.577 0.012 d 0.031 d 0.009 d
  1. aStandardized regression coefficient (negative value indicates negative correlation).
  2. bWald test was used to compare tested haplotype with the remaining haplotypes.
  3. cUncorrected single-point P value.
  4. Permutation p value: dp < 0.05; ep < 0.1. N/A: not applicable