Skip to main content

Table 3 Linear regression analyses for association between quantitative RRB traits and SLC25A12 SNPs after controlling for age, gender and population

From: A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disorders

Sample UIC-UF sample (n = 179 probands) SSC sample (n = 720 probands)
SNP rs2056202 (na = 178) rs908670 (n = 177) rs2292813 (n = 179) rs2056202 (n = 720) rs908670 (n = 718) rs2292813 (n = 720)
Risk allele (frequency) A (0.219) G (0.299) A (0.162) A (0.151) G (0.291) A (0.102)
Stereotyped behavior       
βb 0.201 0.126 0.262 0.187 -0.138 0.055
Statc 1.501 1.075 1.775 2.591 -2.440 0.639
EMP1d 0.138 0.287 0.077 0.008 0.015 0.524
Permutation p 0.303 0.563 0.178 0.026 e 0.040 e 0.851
Self-injurious behavior       
βb 0.196 -0.072 0.276 0.164 -0.168 0.009
Statc 1.413 -0.591 1.807 2.258 -2.966 0.110
EMP1d 0.162 0.552 0.069 0.026 0.003 0.910
Permutation p 0.351 0.870 0.168 0.059 f 0.009 e 0.999
Compulsive behavior       
βb 0.024 0.199 0.138 0.123 -0.093 0.004
Statc 0.174 1.667 0.901 1.669 -1.621 0.049
EMP1d 0.865 0.097 0.375 0.097 0.110 0.960
Permutation p 0.996 0.227 0.692 0.224 0.247 1.000
Ritualistic behavior       
βb 0.298 -0.096 0.414 0.120 -0.029 0.043
Statc 2.173 -0.797 2.761 1.652 -0.511 0.502
EMP1d 0.029 0.420 0.007 0.099 0.617 0.621
Permutation p 0.073 f 0.747 0.017 e 0.233 0.915 0.919
Sameness behavior       
βb 0.284 -0.081 0.420 0.194 -0.062 0.156
Statc 2.036 -0.678 2.757 2.679 -1.087 1.820
EMP1d 0.039 0.497 0.006 0.008 0.281 0.069
Permutation p 0.103 0.827 0.018 e 0.021 e 0.556 0.169
Restricted behavior       
βb 0.096 -0.047 0.279 0.203 -0.068 0.166
Statc 0.703 -0.391 1.840 2.823 -1.208 1.952
EMP1d 0.480 0.691 0.070 0.006 0.230 0.054
Permutation p 0.807 0.953 0.160 0.016 e 0.475 0.127
Sum       
βb 0.260 -0.046 0.390 0.188 -0.110 0.085
Statc 1.848 -0.379 2.548 2.553 -1.917 0.977
EMP1d 0.066 0.701 0.012 0.010 0.052 0.331
Permutation p 0.163 0.961 0.034 e 0.027 e 0.131 0.627
  1. aNumber of subjects with non-missing genotype data available.
  2. bStandardized regression coefficient (negative value indicates negative correlation).
  3. cCoefficient t-statistics.
  4. dUncorrected single-point p value.
  5. Permutation p value: ep < 0.05; fp < 0.1.