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Table 3 Linear regression analyses for association between quantitative RRB traits and SLC25A12 SNPs after controlling for age, gender and population

From: A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disorders

Sample

UIC-UF sample (n = 179 probands)

SSC sample (n = 720 probands)

SNP

rs2056202 (na = 178)

rs908670 (n = 177)

rs2292813 (n = 179)

rs2056202 (n = 720)

rs908670 (n = 718)

rs2292813 (n = 720)

Risk allele (frequency)

A (0.219)

G (0.299)

A (0.162)

A (0.151)

G (0.291)

A (0.102)

Stereotyped behavior

      

βb

0.201

0.126

0.262

0.187

-0.138

0.055

Statc

1.501

1.075

1.775

2.591

-2.440

0.639

EMP1d

0.138

0.287

0.077

0.008

0.015

0.524

Permutation p

0.303

0.563

0.178

0.026 e

0.040 e

0.851

Self-injurious behavior

      

βb

0.196

-0.072

0.276

0.164

-0.168

0.009

Statc

1.413

-0.591

1.807

2.258

-2.966

0.110

EMP1d

0.162

0.552

0.069

0.026

0.003

0.910

Permutation p

0.351

0.870

0.168

0.059 f

0.009 e

0.999

Compulsive behavior

      

βb

0.024

0.199

0.138

0.123

-0.093

0.004

Statc

0.174

1.667

0.901

1.669

-1.621

0.049

EMP1d

0.865

0.097

0.375

0.097

0.110

0.960

Permutation p

0.996

0.227

0.692

0.224

0.247

1.000

Ritualistic behavior

      

βb

0.298

-0.096

0.414

0.120

-0.029

0.043

Statc

2.173

-0.797

2.761

1.652

-0.511

0.502

EMP1d

0.029

0.420

0.007

0.099

0.617

0.621

Permutation p

0.073 f

0.747

0.017 e

0.233

0.915

0.919

Sameness behavior

      

βb

0.284

-0.081

0.420

0.194

-0.062

0.156

Statc

2.036

-0.678

2.757

2.679

-1.087

1.820

EMP1d

0.039

0.497

0.006

0.008

0.281

0.069

Permutation p

0.103

0.827

0.018 e

0.021 e

0.556

0.169

Restricted behavior

      

βb

0.096

-0.047

0.279

0.203

-0.068

0.166

Statc

0.703

-0.391

1.840

2.823

-1.208

1.952

EMP1d

0.480

0.691

0.070

0.006

0.230

0.054

Permutation p

0.807

0.953

0.160

0.016 e

0.475

0.127

Sum

      

βb

0.260

-0.046

0.390

0.188

-0.110

0.085

Statc

1.848

-0.379

2.548

2.553

-1.917

0.977

EMP1d

0.066

0.701

0.012

0.010

0.052

0.331

Permutation p

0.163

0.961

0.034 e

0.027 e

0.131

0.627

  1. aNumber of subjects with non-missing genotype data available.
  2. bStandardized regression coefficient (negative value indicates negative correlation).
  3. cCoefficient t-statistics.
  4. dUncorrected single-point p value.
  5. Permutation p value: ep < 0.05; fp < 0.1.