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Table 3 Western blot analysis results for FMRP, mGluR5, GABRβ3, GFAP and β-actin and their ratios in BA9a

From: Dysregulation of fragile X mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain study

Children

Control

Autistic

Change

P value

Cohen's d

FMRP/β-actin

0.073 ± 0.054

0.119 ± 0.062

↑63%

ns

0.76

mGluR5 dimer/β-actin

0.151 ± 0.179

0.405 ± 0.131

↑168%

0.023b

1.71b

mGluR5 total/β-actin

0.16 ± 0.187

0.466 ± 0.131

↑191%

0.011b

2.01b

GABRβ3/β-actin

0.085 ± 0.049

0.187 ± 0.128

↑120%

ns

0.96b

GFAP/β-actin

1.6 ± 1.16

3.78 ± 0.962

↑136%

0.012b

2.09b

β-actin

20.1 ± 2.94

18.3 ± 4.79

↓8.9%

ns

-

Adults

Control

Autistic

Change

P value

Cohen's d

FMRP/β-actin

0.175 ± 0.075

0.087 ± 0.055

↓50%

0.042b

1.43b

mGluR5 dimer/β-actin

0.136 ± 0.069

0.267 ± 0.175

↑96%

ns

0.87b

mGluR5 total/β-actin

0.139 ± 0.069

0.272 ± 0.178

↑96%

ns

0.87b

GABRβ3/β-actin

0.136 ± 0.069

0.159 ± 0.087

↑17%

ns

0.27

GFAP/β-actin

1.93 ± 0.762

3.04 ± 0.758

↑58%

0.033b

1.46b

β-actin

23.2 ± 1.97

21.7 ± 3.28

↓6.5%

ns

-

  1. aFMRP, fragile X mental retardation protein; mGluR5, metabotropic glutamate receptor 5; GABRβ3, γ-aminobutyric acid (GABA) A receptor β3; GFAP, glial fibrillary acidic protein; BA9, Brodmann's area 9; ns, not significant. bstatistically significant.