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Figure 7 | Molecular Autism

Figure 7

From: Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples

Figure 7

Analysis of ubiquitin ligase 3A (UBE3A) and GABA A receptor β3 (GABRB3) protein levels in postmortem human brain samples. Box-and-whisker plots diagramming protein levels in postmortem human brain tissue normalized to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) by Western blot analysis with a significant increase of UBE3A protein level in duplication of 15q11-q13 (dup15q) (a) and no significant change in GABRB3 protein levels (b). Significant differences are indicated by *P < 0.05 and **P < 0.01. Significant differences in the group means were determined by t-test. Distribution histograms of protein levels of individual brain tissue samples are shown in Additional file 7.

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