Table 3 Genetic score (GS) sensitivities and specificities with their 95% CIs by sex estimated in the exploratory sample
From: Autism risk assessment in siblings of affected children using sex-specific genetic scores
Genetic score threshold | Males | Females | ||
|---|---|---|---|---|
| Â | Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) |
3 | 1.00 | 0.000 | - | - |
4 | 1.00 (0.99 to 1.00) | 0.01 (0.01 to 0.02) | 1.00 | 0.00 |
5 | 0.97 (0.94 to 1.00) | 0.03 (0.02 to 0.05) | 1.00 | 0.00 |
6 | 0.90 (0.85 to 0.94) | 0.19 (0.15 to 0.22) | 1.00 | 0.00 |
7 | 0.75 (0.70 to 0.80) | 0.41 (0.36 to 0.46) | 1.00 | 0.00 |
8 | 0.47 (0.43 to 0.52) | 0.64 (0.59 to 0.69) | 0.99 (0.98 to 1.00) | 0.10 (0.00 to 0.19) |
9 | 0.24 (0.19 to 0.28) | 0.86 (0.82 to 0.90) | 0.90 (0.85 to 0.96) | 0.20 (0.15 to 0.25) |
10 | 0.08 (0.06 to 0.11) | 0.95 (0.92 to 0.97) | 0.78 (0.71 to 0.85) | 0.40 (0.31 to 0.49) |
11 | 0.02 (0.01 to 0.04) | 0.98 (0.96 to 0.99) | 0.61 (0.52 to 0.69) | 0.65 (0.57 to 0.74) |
12 | 0.00 | 1.00 | 0.37 (0.29 to 0.44) | 0.86 (0.80 to 0.92) |
13 | - | - | 0.17 (0.11 to 0.23) | 0.94 (0.89 to 0.98) |
14 | - | - | 0.03 (0.01 to 0.06) | 0.99 (0.97 to 1.00) |