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Table 3 Genetic score (GS) sensitivities and specificities with their 95% CIs by sex estimated in the exploratory sample

From: Autism risk assessment in siblings of affected children using sex-specific genetic scores

Genetic score threshold Males Females
  Sensitivity (95% CI) Specificity (95% CI) Sensitivity (95% CI) Specificity (95% CI)
3 1.00 0.000 - -
4 1.00 (0.99 to 1.00) 0.01 (0.01 to 0.02) 1.00 0.00
5 0.97 (0.94 to 1.00) 0.03 (0.02 to 0.05) 1.00 0.00
6 0.90 (0.85 to 0.94) 0.19 (0.15 to 0.22) 1.00 0.00
7 0.75 (0.70 to 0.80) 0.41 (0.36 to 0.46) 1.00 0.00
8 0.47 (0.43 to 0.52) 0.64 (0.59 to 0.69) 0.99 (0.98 to 1.00) 0.10 (0.00 to 0.19)
9 0.24 (0.19 to 0.28) 0.86 (0.82 to 0.90) 0.90 (0.85 to 0.96) 0.20 (0.15 to 0.25)
10 0.08 (0.06 to 0.11) 0.95 (0.92 to 0.97) 0.78 (0.71 to 0.85) 0.40 (0.31 to 0.49)
11 0.02 (0.01 to 0.04) 0.98 (0.96 to 0.99) 0.61 (0.52 to 0.69) 0.65 (0.57 to 0.74)
12 0.00 1.00 0.37 (0.29 to 0.44) 0.86 (0.80 to 0.92)
13 - - 0.17 (0.11 to 0.23) 0.94 (0.89 to 0.98)
14 - - 0.03 (0.01 to 0.06) 0.99 (0.97 to 1.00)
  1. The two GSs chosen as threshold value to define children with a higher risk of autism in males and in females are shown in bold.